Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.57 |
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | KYNU | Q16719 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10018763 | 1.00 | ALDH1A1 (0.58) | ALDH1A1ALOX15FOLH1CTSKCTSL | |
| SCHEMBL16770327 | 0.93 | CASP1 (0.59) | ALDH1A1ALOX15FOLH1CTSLCASP1 | |
| SCHEMBL16384774 | 0.89 | ALDH1A1 (0.56) | ALDH1A1ALOX15CTSKCTSLCTSS | |
| SCHEMBL20696435 | 0.89 | ALDH1A1 (0.59) | ALDH1A1ALOX15CTSKCTSLCTSS | |
| SCHEMBL13503286 | 0.89 | SMN1; SMN2 (0.57) | ALDH1A1ALOX15CTSKCTSLCTSS | |
| SCHEMBL6946904 | 0.89 | CTSL (0.61) | FOLH1CTSKCTSLCASP1MME | |
| SCHEMBL221391 | 0.89 | KYNU (0.60) | ALDH1A1ALOX15FOLH1CTSKCTSL | |
| SCHEMBL2777678 | 0.89 | KYNU (0.60) | ALDH1A1ALOX15FOLH1CTSKCTSL | |
| SCHEMBL20211867 | 0.89 | CTSL (0.61) | FOLH1CTSKCTSLCASP1MME | |
| SCHEMBL1025916 | 0.89 | CTSL (0.61) | FOLH1CTSKCTSLCASP1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912644-B2 | Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate | CELGENE CORPORATION (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230234914-A1 | PROCESSES FOR THE PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE | CELGENE CORPORATION | 2023-07-27 | — | — | US | disclosed |
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | NUCHEM THERAPEUTICS (CA) | 2016-02-04 | — | — | US | disclosed |
| WO-2014139008-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | ADAERATA, LIMITED PARTNERSHIP (CA) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234914-A1 | PROCESSES FOR THE PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE | UMPS, DHPS, NT5C3B | ALDH1A1 1398/4885ALOX15 1195/4885FOLH1 2859/4885 |
| US-20160031935-A1 | SMALL MOLECULE MODULATORS OF PCSK9 AND METHODS OF USE THEREOF | PCSK9, PCSK7, PCSK6 | ALDH1A1 4355/4885ALOX15 733/4885FOLH1 1200/4885 |
| US-11912644-B2 | Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate | UMPS, DHPS, NT5C3B | ALDH1A1 1398/4885ALOX15 1195/4885FOLH1 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.