Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.46 |
| ▸ | KLK3 | P07288 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16109144 | 0.86 | FFAR2 (0.46) | ALDH1A1KMT2ALMNAPDE4A | |
| SCHEMBL16109170 | 0.78 | KMO (0.61) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL17779981 | 0.78 | P4HB (0.44) | HPSECYP1A2CYP3A4 | |
| SCHEMBL16108852 | 0.78 | MKNK1 (0.59) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL23685091 | 0.74 | CYP11B1 (0.56) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL16108767 | 0.73 | KMO (0.57) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL14003313 | 0.72 | CYP11B1 (0.55) | MKNK1MKNK2CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL29775388 | 0.72 | CYP11B2 (0.61) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL8165131 | 0.72 | CYP11B2 (0.61) | MKNK1MKNK2ABL1CYP11B1CYP11B2 | |
| SCHEMBL18355729 | 0.72 | MKNK1 (0.76) | MKNK1MKNK2ABL1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353089-B2 | Compositions and methods for the treatment of malaria | SAINT LOUIS UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| WO-2014160775-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA | SAINT LOUIS UNIVERSITY (US) | 2014-10-02 | — | — | WO | disclosed |