Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164869 | 0.79 | ALDH1A1 (0.46) | HSD11B1KMT2AALOX12NR3C2ALDH1A1 | |
| SCHEMBL11082175 | 0.73 | MEN1 (0.55) | HSD11B1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL28286235 | 0.73 | LMNA (0.41) | HSD11B1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL12898667 | 0.71 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3625929 | 0.71 | CHRM1 (0.34) | KMT2AMEN1ALOX12ALDH1A1 | |
| SCHEMBL13878052 | 0.69 | ALDH1A1 (0.43) | HSD11B1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL22997584 | 0.67 | HSD11B1 (0.51) | HSD11B1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL22997081 | 0.67 | HSD11B1 (0.51) | HSD11B1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL2962625 | 0.66 | OPRM1 (0.65) | OPRM1OPRD1OPRK1OPRL1TSHR | |
| SCHEMBL13923590 | 0.65 | ALDH1A1 (0.40) | HSD11B1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160039842-A1 | OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS | EPIGENETIX, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20160039842-A1 | OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS | EPIGENETIX, INC. | 2016-02-11 | — | — | US | disclosed |
| WO-2014152029-A2 | OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS | EPIGENETIX, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039842-A1 | OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD2 | HSD11B1 1538/4885OPRM1 2460/4885OPRD1 1809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.