Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | TRPV3 | Q8NET8 | 12/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17518816 | 0.81 | TRPV3 (0.44) | KCNH2TRPV3KDM5B | |
| SCHEMBL17599659 | 0.79 | HEXA (0.42) | TRPV3 | |
| SCHEMBL19390317 | 0.78 | KCNH2 (0.41) | KCNH2TRPV3KDM5B | |
| SCHEMBL1304283 | 0.75 | PTGS2 (0.41) | — | |
| SCHEMBL19405233 | 0.73 | ALDH1A1 (0.39) | KDM5B | |
| SCHEMBL15778792 | 0.72 | FABP4 (0.31) | — | |
| SCHEMBL30641497 | 0.72 | TRPV4 (0.44) | KCNH2TRPV3KDM5B | |
| SCHEMBL19450746 | 0.72 | TRPV3 (0.36) | KCNH2TRPV3KDM5B | |
| SCHEMBL14039561 | 0.72 | METAP2 (0.47) | — | |
| SCHEMBL27909694 | 0.72 | RAD51 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160592-A2 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-10-02 | — | — | WO | disclosed |