Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593355 | 0.82 | ESR1 (0.48) | ALDH1A1CES2CES1NR1I2 | |
| SCHEMBL27353205 | 0.82 | GABBR2 (0.54) | CES2CES1HPGDSMN1; SMN2 | |
| SCHEMBL3568786 | 0.82 | CES2 (0.46) | TSHRALDH1A1HSD17B10CES2CES1 | |
| SCHEMBL9008920 | 0.81 | ESR1 (0.58) | TSHRTP53ALDH1A1HSD17B10CES2 | |
| SCHEMBL4860270 | 0.81 | TSHR (0.52) | TSHRTP53ALDH1A1HSD17B10CES2 | |
| SCHEMBL9184984 | 0.79 | TSHR (0.50) | TSHRTP53ALDH1A1SRD5A2ANPEP | |
| SCHEMBL204589 | 0.79 | TSHR (0.51) | TSHRTP53ALDH1A1HSD17B10CES2 | |
| SCHEMBL19111516 | 0.79 | CES2 (0.43) | ALDH1A1CES2CES1NR1I2 | |
| SCHEMBL14342568 | 0.78 | DEGS1 (0.49) | TSHRTP53ALDH1A1HSD17B10SRD5A2 | |
| SCHEMBL3111366 | 0.78 | TSHR (0.48) | TSHRTP53ALDH1A1HSD17B10CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3031238-A | — | — | None | — | — | JP | disclosed |
| WO-2024182271-A1 | FUSED HETEROTETRACYCLIC ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC | 2018-10-25 | — | — | US | disclosed |
| EP-3310776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
| US-20110237584-A1 | KYNURENINE PRODUCTION INHIBITOR | KYOWA KIRIN CO., LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| US-7923587-B2 | Anti-oxidant macromonomers and polymers and methods of making and using the same | POLNOX CORPORATION (US) | 2011-04-12 | — | — | US | disclosed |
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | EXELIXIS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
| EP-1771530-B1 | ANTI-OXIDANT MACROMONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME | POLNOX CORP (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2060563-A1 | CYCLIC AMINOALKYLCARBOXAMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-05-20 | — | — | EP | disclosed |
| US-20080311065-A1 | Anti-oxidant macromonomers and polymers and methods of making and using the same | POLNOX CORPORATION | 2008-12-18 | — | — | US | disclosed |
| EP-1776394-A2 | ANTI-OXIDANT MACROMONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME | Polnox Corporation (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1771530-A2 | ANTI-OXIDANT MACROMONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME | Polnox Corporation (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20060041087-A1 | Anti-oxidant macromonomers and polymers and methods of making and using the same | POLNOX CORPORATION | 2006-02-23 | — | — | US | disclosed |
| US-20060041094-A1 | Anti-oxidant macromonomers and polymers and methods of making and using the same | POLNOX CORPORATION | 2006-02-23 | — | — | US | disclosed |
| WO-2006014674-A2 | ANTI-OXIDANT MACROMONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME | POLNOX CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |
| WO-2006014605-A2 | ANTI-OXIDANT MACROMONOMERS AND POLYMERS AND METHODS OF MAKING AND USING THE SAME | POLNOX CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |
| JP-H0331238-A | OPTICALLY ACTIVE FLUORINE-CONTAINING BENZOIC ACID DERIVATIVE | KASHIMA SEKIYU KK | 1991-02-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311065-A1 | Anti-oxidant macromonomers and polymers and methods of making and using the same | GPX4, LPO, GPX1 | TSHR 4607/4885TP53 2314/4885ALDH1A1 167/4885 |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | TSHR 2430/4885TP53 758/4885ALDH1A1 4726/4885 |
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | MTOR, RICTOR, RPTOR | TSHR 4423/4885TP53 878/4885ALDH1A1 3391/4885 |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | TSHR 2430/4885TP53 758/4885ALDH1A1 4726/4885 |
| US-20110237584-A1 | KYNURENINE PRODUCTION INHIBITOR | KYNU, KMO, IDO1 | TSHR 1897/4885TP53 3529/4885ALDH1A1 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.