Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22058628 | 0.72 | TSHR (0.54) | LMNATSHRMMP1MMP2MMP3 | |
| SCHEMBL16164002 | 0.68 | HPGD (0.46) | LMNAHSP90AA1HSP90AB1HPGDALDH1A1 | |
| SCHEMBL21331151 | 0.64 | ALDH1A1 (0.56) | TSHRHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL17264206 | 0.64 | LMNA (0.61) | LMNARECQLHSP90AA1HSP90AB1HPGD | |
| SCHEMBL5703500 | 0.64 | HPGD (0.73) | LMNAHSP90AA1HSP90AB1HPGDALDH1A1 | |
| SCHEMBL2045811 | 0.64 | MMP1 (0.42) | LMNARECQLHSP90AA1HSP90AB1MMP1 | |
| SCHEMBL1806308 | 0.62 | HPGD (0.63) | LMNAHSP90AA1HSP90AB1HPGDALDH1A1 | |
| SCHEMBL6001785 | 0.62 | LMNA (0.59) | LMNARECQLHSP90AA1HSP90AB1HPGD | |
| SCHEMBL2457167 | 0.61 | JAK2 (0.37) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL29822323 | 0.60 | TP53 (0.69) | LMNATSHRHSP90AA1HSP90AB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2014-10-16 | — | — | US | claimed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | LMNA 3155/4885RECQL 115/4885TSHR 598/4885 |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | LMNA 3155/4885RECQL 115/4885TSHR 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.