Sugi Predict

Sugi Predict / Compounds / SCHEMBL1616599

SCHEMBL1616599

SCHEMBL1616599

CC(C)[C@@H]1CC[C@@H](C)CC1C(=O)Nc1ccc(CC(N)=O)cc1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 4/20 0.66
▸ EPHX1 P07099 1/20 0.50
▸ CYP19A1 P11511 2/20 0.42
▸ POLB P06746 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ SERPINE1 P05121 1/20 0.40
▸ MEN1 O00255 3/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ LMNA P02545 1/20 0.38
▸ TRPV1 Q8NER1 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ P2RX4 Q99571 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18241834 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL28574384 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL29007018 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL28589008 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL12422177 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL23187800 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL20226803 1.00 TRPM8 (0.66) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL12715179 0.89 TRPM8 (0.67) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL4889653 0.89 TRPM8 (0.67) TRPM8EPHX1CYP19A1POLBTSHR
SCHEMBL14022692 0.88 TRPM8 (0.69) TRPM8EPHX1CYP19A1SERPINE1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9668497-B2 Flavor-enhancing compounds INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2017-06-06 — — US claimed
US-20170086476-A1 FLAVOR-ENHANCING COMPOUNDS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2017-03-30 — — US claimed
US-20240108040-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2024-04-04 — — US disclosed
EP-2775839-B1 METHODS FOR ASSESSING REPELLANT QUALITY OF ORGANIC MATERIALS AND METHODS AND COMPOSITIONS FOR REPELLING ARTHROPODS UNIV CALIFORNIA (US) 2023-12-06 — — EP disclosed
US-11758933-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2023-09-19 — — US disclosed
EP-3368542-B1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2022-06-22 — — EP disclosed
US-11357246-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2022-06-14 — — US disclosed
US-20210227863-A1 HIGH INTENSITY SWEETENERS SENOMYX, INC. 2021-07-29 — — US disclosed
CN-108473484-B Compounds useful as TRPM8 modulators 弗门尼舍公司 2021-06-29 — — CN disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 — — US disclosed
WO-2017075257-A2 HIGH INTENSITY SWEETENERS SENOMYX, INC. (US) 2017-05-04 — — WO disclosed
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2017-04-06 — — US disclosed
US-20170086476-A1 FLAVOR-ENHANCING COMPOUNDS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2017-03-30 — — US disclosed
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION SENOMYX INC (US) 2017-03-30 — — US disclosed
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF SENOMYX INC (US) 2016-12-29 — — US disclosed
US-8487130-B2 Menthylcarboxamides and their use as cooling agents INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2013-07-16 — — US disclosed
US-20110195032-A1 Menthylcarboxamides and Their Use as Cooling Agents KAZIMIERSKI ARKADIUSZ 2011-08-11 — — US disclosed
US-7923577-B2 Menthylcarboxamides and their use as cooling agents INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 2011-04-12 — — US disclosed
US-20100272655-A1 Menthylcarboxamides and Their Use as Cooling Agents BARDSLEY KATHRYN ANNE 2010-10-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240108040-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 TRPM8 180/4885EPHX1 3026/4885CYP19A1 4650/4885
US-20110195032-A1 Menthylcarboxamides and Their Use as Cooling Agents GMDS, CHIA, RIMKLA TRPM8 59/4885EPHX1 1156/4885CYP19A1 1635/4885
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF TAS2R5, TAS1R1, TAS2R1 TRPM8 70/4885EPHX1 3681/4885CYP19A1 3584/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 TRPM8 1/4885EPHX1 4010/4885CYP19A1 4071/4885
US-11357246-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 TRPM8 180/4885EPHX1 3026/4885CYP19A1 4650/4885
US-20170086476-A1 FLAVOR-ENHANCING COMPOUNDS TAS2R8, TAS2R40, TAS2R7 TRPM8 122/4885EPHX1 2981/4885CYP19A1 2253/4885
US-20100272655-A1 Menthylcarboxamides and Their Use as Cooling Agents GMDS, CHIA, RIMKLA TRPM8 59/4885EPHX1 1156/4885CYP19A1 1635/4885
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION TRPA1, PDE6G, PDE6D TRPM8 97/4885EPHX1 3152/4885CYP19A1 577/4885
US-20210227863-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 TRPM8 180/4885EPHX1 3026/4885CYP19A1 4650/4885
US-11758933-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 TRPM8 180/4885EPHX1 3026/4885CYP19A1 4650/4885
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 TRPM8 1/4885EPHX1 3982/4885CYP19A1 3947/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.