SCHEMBL16167178

SCHEMBL16167178

C=CC(=O)N(C)c1cc(Br)ccc1Br

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.41
EGFR P00533 3/20 0.40
KDR P35968 1/20 0.37
TGM2 P21980 3/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 3/20 0.35
F13A1 P00488 1/20 0.35
TGM1 P22735 1/20 0.35
TGM3 Q08188 1/20 0.35
NCEH1 Q6PIU2 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HSP90AA1 P07900 1/20 0.33
TLR9 Q9NR96 1/20 0.33
RECQL P46063 1/20 0.33
RAB9A P51151 1/20 0.33
CYP2C19 P33261 1/20 0.33
MAPT P10636 1/20 0.33
BTK Q06187 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16095632 0.85 EGFR (0.39) EGFRKDRTGM2ALDH1A1LMNA
SCHEMBL31289612 0.77 MAPK3 (0.37) EGFRKDRTGM2ALDH1A1LMNA
SCHEMBL29240828 0.73 PIM1 (0.50) EGFRKDRLMNARAB9AMAPT
SCHEMBL16974396 0.72 ALDH1A1 (0.31) TGM2ALDH1A1LMNANPSR1CYP2C19
SCHEMBL9485990 0.69 CCR5 (0.42) SIGMAR1ALDH1A1NCEH1HSP90AA1TLR9
SCHEMBL7521732 0.69 MAPT (0.35) SIGMAR1ALDH1A1LMNANCEH1HSP90AA1
SCHEMBL28880650 0.68 HTT (0.53) EGFRKDRALDH1A1LMNAMAPT
SCHEMBL29249801 0.68 LMNA (0.43) EGFRTGM2ALDH1A1LMNAF13A1
SCHEMBL27966636 0.68 BTK (0.40) ALDH1A1LMNARAB9AMAPTBTK
SCHEMBL27427344 0.68 SIGMAR1 (0.42) SIGMAR1ALDH1A1HSP90AA1TLR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3024456-A1 COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE Update Pharma Inc. (US) 2016-06-01 EP disclosed
EP-3024457-A1 COMPOSITIONS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE Update Pharma Inc. (US) 2016-06-01 EP disclosed
EP-2983674-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS Brown, Dennis M. (US) 2016-02-17 EP disclosed
WO-2015013579-A1 COMPOSITIONS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE UPDATE PHARMA INC. (US) 2015-01-29 WO disclosed
WO-2015013581-A1 COMBINATORIAL METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE UPDATE PHARMA INC. (US) 2015-01-29 WO disclosed
WO-2014168986-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS BROWN DENNIS M (US) 2014-10-16 WO disclosed