Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | CXCR4 | P61073 | 7/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28208414 | 0.95 | CXCR4 (0.61) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| Pyrrolidine SCHEMBL15516038 | 0.87 | SIGMAR1 (0.72) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL26789 | 0.87 | SIGMAR1 (0.78) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL6632216 | 0.86 | SIGMAR1 (0.82) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL27713050 | 0.85 | SIGMAR1 (0.75) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL24271305 | 0.84 | SIGMAR1 (0.79) | SIGMAR1CXCR4ALDH1A1MEN1KMT2A | |
| SCHEMBL3779720 | 0.83 | CXCR4 (0.78) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL27300143 | 0.83 | SIGMAR1 (0.77) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL15046526 | 0.81 | CXCR4 (0.75) | SIGMAR1CXCR4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL13952 | 0.80 | SIGMAR1 (0.81) | SIGMAR1CYP2D6ALDH1A1HRH3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877463-B1 | A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | SANIONA AS (DK) | 2018-11-07 | — | — | EP | disclosed |
| US-9931329-B2 | Phenyl triazole derivative and its use for modulating the GABAA receptor complex | SANIONA A/S (DK) | 2018-04-03 | — | — | US | disclosed |
| US-9884848-B2 | Phenyl triazole derivative and its use for modulating the GABAA receptor complex | SANIONA A/S (DK) | 2018-02-06 | — | — | US | disclosed |
| EP-2885290-B1 | A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | SANIONA AS (DK) | 2017-10-18 | — | — | EP | disclosed |
| US-20170226072-A1 | 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds | UNIV KENTUCKY RES FOUND (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170114045-A1 | PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | SANIONA AS (DK) | 2017-04-27 | — | — | US | disclosed |
| US-9475797-B2 | Phenyl triazole derivative and its use for modulating the GABAA receptor complex | SANIONA A/S (DK) | 2016-10-25 | — | — | US | disclosed |
| US-20160115155-A1 | A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | SANIONA APS (DK) | 2016-04-28 | — | — | US | disclosed |
| US-20160067234-A1 | PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | SANIONA APS (DK) | 2016-03-10 | — | — | US | disclosed |
| US-20160031840-A1 | 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-02-04 | — | — | US | disclosed |
| WO-2006108800-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-19 | — | — | WO | disclosed |
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | ANIONA APS (DK) | 2006-07-06 | — | — | US | disclosed |
| US-20060069135-A1 | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex | NEUROSEARCH A/S (DK) | 2006-03-30 | — | — | US | disclosed |
| EP-1613312-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA sb A /sb RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| EP-1613618-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA- sb A /sb RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087137-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
| WO-2004087690-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-A RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
| US-6040303-A | NEUROKININ-RECEPTOR ANTAGONISTS, ANTIINFLAMMATORY AGENTS FOR TREATING GASTROINTESTINAL DISORDERS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2000-03-21 | — | — | US | disclosed |
| WO-1997045422-A1 | ANTI-NEURODEGENERATIVELY EFFECTIVE 10-AMINOALIPHATYL-DIBENZ[b,f]OXEPINE SALTS | NOVARTIS AG (CH) | 1997-12-04 | — | — | WO | disclosed |
| US-4788189-A | Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking | GLAZER HOWARD I (US) | 1988-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069135-A1 | Benzimidazole derivatives and their use for modulating the gaba-a receptor complex | GABRB2, GABRB1, GABRB3 | SIGMAR1 232/4885CXCR4 1935/4885CYP2D6 1217/4885 |
| US-20160067234-A1 | PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | GABRB3, GABRB1, GABRA5 | SIGMAR1 153/4885CXCR4 2187/4885CYP2D6 1489/4885 |
| US-20170114045-A1 | PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | GABRA5, GABRB3, GABRB1 | SIGMAR1 175/4885CXCR4 1254/4885CYP2D6 1239/4885 |
| US-20160115155-A1 | A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | GABRB3, GABRB1, GABRB2 | SIGMAR1 171/4885CXCR4 1310/4885CYP2D6 1673/4885 |
| US-20160031840-A1 | 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds | GRM1, BRD4, DRD1 | SIGMAR1 1327/4885CXCR4 576/4885CYP2D6 1085/4885 |
| US-20170226072-A1 | 1,4-Disubstituted Piperidines, 1,4-Disubstituted Piperazines, 1,4-Disubstituted Diazepines, and 1,3-Disubstituted Pyrrolidine Compounds | GRM1, BRD4, DRD1 | SIGMAR1 1327/4885CXCR4 576/4885CYP2D6 1085/4885 |
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | GABRB2, GABRB1, GABRB3 | SIGMAR1 196/4885CXCR4 1877/4885CYP2D6 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.