Crotonic Acid

Crotonic Acid

SCHEMBL1618932

C=CCC(=O)O.CC=CC(=O)O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP2D6 P10635 1/20 0.36
ABCC4 O15439 1/20 0.35
MAPT P10636 1/20 0.35
TSHR P16473 3/20 0.35
TP53 P04637 1/20 0.35
EGLN1 Q9GZT9 1/20 0.35
EGLN3 Q9H6Z9 1/20 0.35
LMNA P02545 2/20 0.33
HCAR2 Q8TDS4 2/20 0.31
HSD17B10 Q99714 1/20 0.31
GABRR1 P24046 2/20 0.31
GABRR2 P28476 2/20 0.31
BLM P54132 2/20 0.31
GABRR3 A8MPY1 1/20 0.31
APEX1 P27695 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Crotonic Acid SCHEMBL11525007 1.00 ALOX15 (0.36) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Crotonic Acid SCHEMBL2406680 1.00 ALOX15 (0.36) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Crotonic Acid SCHEMBL27396103 0.94 FFAR3 (0.40) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Crotonic Acid SCHEMBL7029699 0.86
Fumaric Acid SCHEMBL4979324 0.85 TSHR (0.50) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Fumaric Acid SCHEMBL3703148 0.85 TSHR (0.50) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Maleic Acid SCHEMBL3703143 0.85 TSHR (0.50) ALOX15ALDH1A1CYP2D6ABCC4MAPT
Phthalic Acid SCHEMBL7201091 0.83 ALDH1A1 (0.44) ALOX15ALDH1A1MAPTHSD17B10TDP1
Propene SCHEMBL27524776 0.83
Crotonic Acid SCHEMBL28077513 0.83 MAPT (0.52) ALDH1A1CYP2D6ABCC4MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107022326-A The IMD glue of roof panels high adhesion force 滁州金桥德克新材料有限公司 2017-08-08 CN claimed
CN-103946325-B Aqueous coating compositions 湛新奥地利有限公司 2017-02-15 CN claimed
CN-102271661-A Hot-melt extrusion of modified release multi-particulates 2011-12-07 CN claimed
CN-1250647-A Thickening agent used for compositions contg. surfactant BASF AG (DE) 2000-04-19 CN claimed
US-5929196-A FOR USE IN THE PREPARATION OF SUSTAINED-RELEASE DRUGS SCHWARZ PHARMA AG (DE) 1999-07-27 US claimed
EP-0153104-B1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM BENZON PHARMA A/S (DK) 1993-04-21 EP claimed
EP-0153105-B1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM BENZON PHARMA A/S (DK) 1992-09-09 EP claimed
US-4727109-A SUSTAINED RELEASE R. P. SCHERER CORPORATION (US) 1988-02-23 US claimed
US-4716041-A SUSTAINED RELEASE A/S ALFRED BENZON (DK) 1987-12-29 US claimed
US-4713248-A MIXTURE OF FILM FORMING AGENT WITH COMPRESSIBLE POLYMER A/S ALFRED BENZON (DK) 1987-12-15 US claimed
CN-85103362-A DENTAL FLOSS 1986-12-10 CN claimed
EP-0153105-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP claimed
EP-0153104-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP claimed
WO-1985003437-A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM A/S ALFRED BENZON (DK) 1985-08-15 WO claimed
WO-1985003436-A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM A/S ALFRED BENZON (DK) 1985-08-15 WO claimed
EP-4314121-A1 COLOR MASTERBATCH FOR PRODUCING A COLORED PLASTIC ARTICLE AND METHOD FOR DECOLORING THE COLORED PLASTIC ARTICLE Smart Coloring GmbH (DE) 2024-02-07 EP disclosed
US-20210251997-A1 PALIPERIDONE FOR TREATMENT OF DRUG REFRACTORY IRRITABILITY AND AUTISM SPECTRUM DISORDER CHILDRENS HOSPITAL MED CT (US) 2021-08-19 US disclosed
US-3985499-A Diazamerocyanines for dyeing keratinous fibers L'OREAL (FR) 1976-10-12 US disclosed
US-3968310-A Half-ester reaction products of maleated alpha-olefins and monohydric alcohols A. E. STALEY MANUFACTURING COMPANY (US) 1976-07-06 US disclosed
US-3933885-A Cinnamylideneacetic acid esters FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210251997-A1 PALIPERIDONE FOR TREATMENT OF DRUG REFRACTORY IRRITABILITY AND AUTISM SPECTRUM DISORDER DRD2, DRD1, DRD3 ALOX15 2336/4885ALDH1A1 535/4885CYP2D6 541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.