Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200058 | 0.81 | HSD11B1 (0.40) | POLBMAPTTP53KDM4EHPGD | |
| SCHEMBL14044106 | 0.76 | PTGS2 (0.43) | PTGS2PTGS1MAPTGAALMNA | |
| SCHEMBL16200214 | 0.69 | ADORA2A (0.40) | PTGS2PTGS1RECQLKDM4EALDH1A1 | |
| SCHEMBL13066184 | 0.67 | PTGS2 (0.33) | PTGS2PTGS1 | |
| SCHEMBL16200388 | 0.67 | THRB (0.45) | POLBRECQLTDP1MAPTTP53 | |
| SCHEMBL16200046 | 0.67 | MEN1 (0.41) | PTGS2PTGS1KDM4EALDH1A1HSD11B1 | |
| SCHEMBL16200074 | 0.67 | POLB (0.40) | PTGS2PTGS1POLBLMNAMBNL1 | |
| SCHEMBL16200208 | 0.67 | MAPK1 (0.44) | PTGS2PTGS1TDP1MAPTKDM4E | |
| SCHEMBL27894720 | 0.66 | POLB (0.45) | POLBRECQLTDP1MAPTLMNA | |
| SCHEMBL8569766 | 0.66 | HSD11B1 (0.47) | CNR2MAPK14MAPTNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |