Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235761 | 0.83 | PTGS2 (0.36) | POLBMAPK1GAAPTGS2MEN1 | |
| SCHEMBL16234965 | 0.68 | ESR1 (0.36) | POLBGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL16235054 | 0.67 | HTT (0.31) | MAPTSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL16235080 | 0.66 | SMN1; SMN2 (0.45) | MAPK1GAAKMT2AALDH1A1MAPT | |
| SCHEMBL16235076 | 0.66 | TSHR (0.49) | POLBMAPK1ALDH1A1MAPTLMNA | |
| SCHEMBL30602424 | 0.64 | MAPT (0.36) | MAPK1GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL29131000 | 0.64 | MAPT (0.36) | MAPK1GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL16235789 | 0.64 | ALDH1A1 (0.33) | ALDH1A1MAPTLMNAHTT | |
| SCHEMBL529036 | 0.61 | NPSR1 (0.41) | POLBGAAMEN1KMT2AMAPT | |
| SCHEMBL16234970 | 0.59 | ALDH1A1 (0.31) | MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |