Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239497 | 0.93 | L3MBTL1 (0.43) | KMT2AMOGAT2HSD11B1ALDH1A1ESR1 | |
| SCHEMBL16239989 | 0.92 | IMPDH2 (0.40) | KMT2AHTR6ALDH1A1MAPTLMNA | |
| SCHEMBL16240087 | 0.88 | GPR119 (0.41) | KMT2AALDH1A1ESR1MAPTTP53 | |
| SCHEMBL16239481 | 0.87 | BRD4 (0.36) | POLBALDH1A1LMNAPGR | |
| SCHEMBL16239479 | 0.87 | BRD4 (0.38) | KMT2A | |
| SCHEMBL16239627 | 0.86 | KMT2A (0.41) | KMT2APOLBPKMHSD11B1ALDH1A1 | |
| SCHEMBL2133368 | 0.83 | PKM (0.41) | KMT2APOLBPKMHTR6HSD11B1 | |
| SCHEMBL2136004 | 0.79 | PKM (0.44) | KMT2APOLBPKMHSD11B1ALDH1A1 | |
| SCHEMBL16240075 | 0.79 | L3MBTL1 (0.45) | KMT2AHSD11B1ALDH1A1ESR1MAPT | |
| SCHEMBL16239486 | 0.78 | HPGD (0.43) | KMT2AHTR6ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |