Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626519 | 0.88 | ALDH1A1 (0.34) | PRMT5WDR77ALDH1A1MAPTHSD17B10 | |
| SCHEMBL14236989 | 0.83 | MCOLN2 (0.41) | PRMT5WDR77HPGDDPP8HTR6 | |
| Hydrochloric Acid SCHEMBL1626825 | 0.82 | MCOLN2 (0.40) | PRMT5WDR77ALDH1A1MAPTHSD17B10 | |
| SCHEMBL14237049 | 0.79 | HTR6 (0.39) | PRMT5ALDH1A1MAPTHPGDDPP8 | |
| SCHEMBL14237070 | 0.79 | HTR6 (0.35) | PRMT5WDR77MAPTDPP8HTR6 | |
| Hydrochloric Acid SCHEMBL1627665 | 0.78 | HTR6 (0.39) | PRMT5ALDH1A1MAPTHPGDDPP8 | |
| SCHEMBL14237095 | 0.78 | TSHR (0.46) | PRMT5ALDH1A1KDM4EHPGDDPP8 | |
| Hydrochloric Acid SCHEMBL5922603 | 0.78 | HTR6 (0.35) | PRMT5WDR77ALDH1A1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL1627703 | 0.78 | TSHR (0.45) | PRMT5ALDH1A1DPP8HTR6MEN1 | |
| SCHEMBL14236996 | 0.78 | CHRNB2 (0.35) | PRMT5WDR77DPP8HTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831195-B1 | 5-HT7 RECEPTOR ANTAGONISTS | ESTEVE LABOR DR (ES) | 2012-12-19 | — | — | EP | claimed |
| EP-1831195-B1 | 5-HT7 RECEPTOR ANTAGONISTS | ESTEVE LABOR DR (ES) | 2012-12-19 | — | — | EP | disclosed |
| US-7928121-B2 | 2-[1-(5-Chloro-2,4-difluoro-benzenesulfonyl)-piperidin-4-ylmethyl]-1,2,3,4-tetrahydroisoquinolinehydrochloride; antidepressant, anxiolytic, hypotensive agent; psychosis, schizophrenia, migraine, cognition activity; pharmacokinetics | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-04-19 | — | — | US | disclosed |
| US-20080214603-A1 | 5-Ht7 Receptor Antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-09-04 | — | — | US | disclosed |
| US-7345057-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-03-18 | — | — | US | disclosed |
| US-20060142332-A1 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214603-A1 | 5-Ht7 Receptor Antagonists | HTR7, HTR1A, HTR5A | PRMT5 1967/4885WDR77 3403/4885ALDH1A1 2903/4885 |
| US-20060142332-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | PRMT5 2071/4885WDR77 3421/4885ALDH1A1 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.