Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19289791 | 0.86 | AKT1 (0.42) | CA2SMN1; SMN2ALDH1A1KDM4ECYP4F2 | |
| SCHEMBL6069968 | 0.86 | CA2 (0.51) | CA2ALDH1A1HPGDHSD17B10AKR1B1 | |
| SCHEMBL510145 | 0.83 | ALDH1A1 (0.45) | CA2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL31254084 | 0.83 | ALDH1A1 (0.45) | CA2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3790563 | 0.82 | TRPA1 (0.43) | RAB9ASMN1; SMN2ALDH1A1KDM4ECYP4F2 | |
| SCHEMBL31162368 | 0.82 | CA2 (0.47) | CA2RAB9AGFERSMN1; SMN2KDM4E | |
| SCHEMBL14420099 | 0.81 | TSHR (0.44) | RAB9AGFERSMN1; SMN2ALDH1A1CYP4F2 | |
| SCHEMBL17424894 | 0.80 | SMN1; SMN2 (0.45) | CA2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL9411180 | 0.79 | PKM (0.47) | PTGDR2ALDH1A1KDM4ECXCL8CYP2C9 | |
| SCHEMBL19289794 | 0.79 | TRPA1 (0.38) | RAB9ASMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004061-B1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | LILLY CO ELI (US) | 2017-08-30 | — | — | EP | disclosed |
| US-8962654-B2 | 3,4-dihydroisoquinolin-2(1H)-yl compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962654-B2 | 3,4-dihydroisoquinolin-2(1H)-yl compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962654-B2 | 3,4-dihydroisoquinolin-2(1H)-yl compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | US | disclosed |
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | PARK7, SNCA, COMT | CA2 4261/4885PTGDR2 587/4885RAB9A 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.