Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392990 | 0.98 | ACHE (0.46) | ACHEMAPTALDH1A1POLBKDM4E | |
| SCHEMBL28183847 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1POLBKDM4EGFER | |
| SCHEMBL28958866 | 0.78 | ACHE (0.42) | ACHEMAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL16707585 | 0.75 | ALDH1A1 (0.46) | ACHEMAPTALDH1A1POLBGFER | |
| SCHEMBL23554066 | 0.72 | DDB1 (0.45) | MAPTALDH1A1POLBL3MBTL1DDB1 | |
| SCHEMBL14409994 | 0.72 | ALDH1A1 (0.38) | MAPTALDH1A1POLBGFERHTT | |
| SCHEMBL31408760 | 0.72 | CYP3A4 (0.46) | MAPTALDH1A1POLBKDM4EMAPK1 | |
| SCHEMBL6245615 | 0.72 | KMT2A (0.39) | MAPTALDH1A1POLBKDM4EL3MBTL1 | |
| SCHEMBL13764455 | 0.72 | ALDH1A1 (0.38) | MAPTALDH1A1POLBKDM4EGFER | |
| SCHEMBL11056267 | 0.72 | CYP3A4 (0.46) | MAPTALDH1A1POLBKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932416-B2 | Prepared by electrophilic aromatic substitution via halogenation, chlorosulfonation or nitration of a pentafluorosulfanylbenzene; 2-Methyl-5-nitro-4-pentafluorosulfuranylbenzoic acid; for liquid crystals, polymers, pesticides, herbicides, fungicides, nematocides, parasiticides, insecticides, acaricides | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-04-26 | — | — | US | disclosed |
| US-7659429-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-09 | — | — | US | disclosed |
| US-7622611-B2 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-11-24 | — | — | US | disclosed |
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-7449594-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-11 | — | — | US | disclosed |
| US-20080146673-A1 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESS FOR THEIR PREPARATION, USE AS A MEDICAMENT OR DIAGNOSTIC AID, AND MEDICAMENT COMPRISING SAME | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
| US-20080091031-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | SANOFI-AVENTIS DEUTSCHLAND GMBH (FR) | 2008-04-17 | — | — | US | disclosed |
| US-7317124-B2 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-01-08 | — | — | US | disclosed |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| US-7126026-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-10-24 | — | — | US | disclosed |
| US-20050148652-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-07-07 | — | — | US | disclosed |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-16 | — | — | US | disclosed |
| US-20050124666-A1 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148652-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | PFAS, DDT, PNPO | ACHE 15/4885MAPT 1519/4885ALDH1A1 793/4885 |
| US-20080146673-A1 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESS FOR THEIR PREPARATION, USE AS A MEDICAMENT OR DIAGNOSTIC AID, AND MEDICAMENT COMPRISING SAME | TNNI3, TNNT2, FABP3 | ACHE 591/4885MAPT 4877/4885ALDH1A1 172/4885 |
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | ACHE 3326/4885MAPT 4785/4885ALDH1A1 512/4885 |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | ACHE 3326/4885MAPT 4785/4885ALDH1A1 512/4885 |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | PAH, NCEH1, PNMT | ACHE 1758/4885MAPT 4482/4885ALDH1A1 430/4885 |
| US-20080091031-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | PFAS, DDT, PNPO | ACHE 15/4885MAPT 1519/4885ALDH1A1 793/4885 |
| US-20050124666-A1 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | TNNI3, TNNT2, FABP3 | ACHE 591/4885MAPT 4877/4885ALDH1A1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.