Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.63 |
| ▸ | BCL2 | P10415 | 1/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24089198 | 0.86 | EP300 (0.81) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL2411718 | 0.86 | PARP10 (0.56) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL10304691 | 0.86 | KMT2A (0.53) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL3545163 | 0.84 | KMT2A (0.58) | EP300KMT2ACA12CA1CA2 | |
| SCHEMBL3544032 | 0.83 | MAPT (0.54) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL16369801 | 0.83 | CA12 (0.54) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL13846096 | 0.83 | LMNA (0.47) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL14452820 | 0.82 | EP300 (0.56) | EP300BCL2BCL2L1MCL1BAK1 | |
| SCHEMBL27747073 | 0.81 | ALDH1A1 (0.56) | EP300BCL2L1KMT2ACA12CA1 | |
| SCHEMBL11672654 | 0.81 | HTT (0.66) | EP300KMT2ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |
| US-11225503-B2 | Crystobactamides | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-01-18 | — | — | US | disclosed |
| EP-3224238-B1 | NOVEL CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2021-08-11 | — | — | EP | disclosed |
| EP-3019615-B1 | CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2021-04-07 | — | — | EP | disclosed |
| CN-105793424-B | Ascomycetes amides | 亥姆霍兹感染研究中心有限公司 | 2021-02-19 | — | — | CN | disclosed |
| US-20200331964-A1 | CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2020-10-22 | — | — | US | disclosed |
| US-10793600-B2 | Cystobactamides | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-10-06 | — | — | US | disclosed |
| US-10519099-B2 | Cystobactamides | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2019-12-31 | — | — | US | disclosed |
| US-20190185514-A1 | CYSTOBACTAMIDES | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
| US-20170327458-A1 | NOVEL CYSTOBACTAMIDES | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2017-11-16 | — | — | US | disclosed |
| CN-105793424-A | Ascomycetes amides | 亥姆霍兹感染研究中心有限公司 | 2016-07-20 | — | — | CN | disclosed |
| US-20160145304-A1 | CYSTOBACTAMIDES | HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) | 2016-05-26 | — | — | US | disclosed |
| EP-3019615-A2 | CYSTOBACTAMIDES | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2016-05-18 | — | — | EP | disclosed |
| WO-2015003816-A2 | CYSTOBACTAMIDES | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2015-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145304-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, CBS | EP300 3526/4885BCL2 2186/4885BCL2L1 1794/4885 |
| US-20170327458-A1 | NOVEL CYSTOBACTAMIDES | SLC7A11, CTH, CBS | EP300 4074/4885BCL2 3241/4885BCL2L1 2277/4885 |
| US-11225503-B2 | Crystobactamides | PKD2, SLC7A11, CTH | EP300 4199/4885BCL2 2103/4885BCL2L1 711/4885 |
| US-20190185514-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, SULT2A1 | EP300 3359/4885BCL2 3703/4885BCL2L1 1668/4885 |
| US-10519099-B2 | Cystobactamides | CTH, TST, CBS | EP300 3800/4885BCL2 2317/4885BCL2L1 2136/4885 |
| US-20200331964-A1 | CYSTOBACTAMIDES | CTH, SLC7A11, SULT2A1 | EP300 3416/4885BCL2 3481/4885BCL2L1 1489/4885 |
| US-10793600-B2 | Cystobactamides | CTH, SLC7A11, SULT2A1 | EP300 3514/4885BCL2 3856/4885BCL2L1 1795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.