Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | CETP | P11597 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908896 | 0.85 | ALDH1A1 (0.63) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL1672672 | 0.85 | CRHBP (0.58) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL11440294 | 0.83 | ALDH1A1 (0.71) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL31068669 | 0.83 | ALDH1A1 (0.71) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL9304794 | 0.81 | ALDH1A1 (0.73) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL28495975 | 0.77 | ALDH1A1 (0.53) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL9322653 | 0.76 | ALDH1A1 (0.56) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL10907115 | 0.76 | ALDH1A1 (0.55) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL8084726 | 0.76 | ALDH1A1 (0.59) | ALDH1A1CYP3A4OPRM1OPRD1OPRK1 | |
| SCHEMBL13404667 | 0.75 | CETP (0.64) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160115146-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | CISTIM (BE) | 2016-04-28 | — | — | US | disclosed |
| US-20160115146-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | CISTIM (BE) | 2016-04-28 | — | — | US | disclosed |
| US-20160115146-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | CISTIM (BE) | 2016-04-28 | — | — | US | disclosed |
| EP-3004073-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | Université catholique de Louvain (BE) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014195507-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2014-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115146-A1 | 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES | SLC16A3, SLC16A1, SLC16A8 | ALDH1A1 160/4885CYP3A4 141/4885OPRM1 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.