Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 9/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403930 | 0.97 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1SCD5 | |
| SCHEMBL16404125 | 0.84 | SCD (0.47) | SMN1; SMN2ALDH1A1ROCK2SCDMAPT | |
| SCHEMBL16403957 | 0.83 | HSD17B10 (0.52) | NPC1RAB9ASCD5ROCK2HSD17B10 | |
| SCHEMBL16403960 | 0.83 | SCD (0.42) | SMN1; SMN2SCD5ROCK2HSD17B10SCD | |
| SCHEMBL16403934 | 0.76 | TRPV1 (0.40) | NPC1RAB9AALDH1A1SCD5ROCK2 | |
| SCHEMBL16403958 | 0.76 | HCRTR1 (0.48) | SCD5ROCK2SCDHCRTR1HCRTR2 | |
| SCHEMBL16404086 | 0.76 | SCD (0.42) | SMN1; SMN2SCD5HSD17B10SCDHCRTR1 | |
| SCHEMBL16403918 | 0.71 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1ROCK2 | |
| SCHEMBL16403992 | 0.71 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL16403916 | 0.71 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |