Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RHOA | P61586 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403916 | 0.87 | ALDH1A1 (0.48) | NPC1RAB9AALDH1A1PKMRHOA | |
| SCHEMBL16403992 | 0.86 | RAB9A (0.60) | NPC1RAB9AALDH1A1PKMRHOA | |
| SCHEMBL16404112 | 0.80 | ATP4A (0.53) | NPC1RAB9AALDH1A1PKMRHOA | |
| SCHEMBL16403979 | 0.75 | MGLL (0.48) | NPC1RAB9AALDH1A1PKMHPGD | |
| SCHEMBL16403957 | 0.73 | HSD17B10 (0.52) | NPC1RAB9AROCK2 | |
| SCHEMBL16404113 | 0.73 | CCNC (0.55) | NPC1RAB9AALDH1A1PKMGFER | |
| SCHEMBL16403966 | 0.73 | LMNA (0.55) | ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14684758 | 0.72 | LMNA (0.53) | NPC1RAB9AALDH1A1PKMHPGD | |
| SCHEMBL16404125 | 0.72 | SCD (0.47) | ALDH1A1GAASMN1; SMN2ROCK2MAPK1 | |
| SCHEMBL16403934 | 0.71 | TRPV1 (0.40) | NPC1RAB9AALDH1A1PKMGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |