Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403916 | 0.80 | ALDH1A1 (0.48) | LMNANPSR1MAPTUSP2ALDH1A1 | |
| SCHEMBL16403992 | 0.77 | RAB9A (0.60) | LMNANPSR1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL16403979 | 0.77 | MGLL (0.48) | LMNAMAPTUSP2TP53ALDH1A1 | |
| SCHEMBL16403927 | 0.73 | ALDH1A1 (0.49) | LMNAMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL16403918 | 0.73 | NPC1 (0.47) | LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17689220 | 0.71 | LMNA (0.64) | LMNAHTR2BTHRBNPSR1MAPT | |
| SCHEMBL5014847 | 0.70 | LMNA (0.73) | LMNAHTR2BTHRBNPSR1MAPT | |
| SCHEMBL14318296 | 0.70 | HPGD (0.45) | ALDH1A1 | |
| SCHEMBL14684786 | 0.69 | KCNA5 (0.54) | TP53ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13810503 | 0.68 | LMNA (0.61) | LMNAHTR2BTHRBNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |