Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057707 | 0.84 | KEAP1 (0.40) | KEAP1NFE2L2PTGS2 | |
| SCHEMBL29131036 | 0.77 | PTPN1 (0.32) | — | |
| SCHEMBL16440019 | 0.74 | KEAP1 (0.38) | KEAP1NFE2L2 | |
| SCHEMBL5187074 | 0.74 | KEAP1 (0.34) | KEAP1NFE2L2PTGS2 | |
| SCHEMBL9118988 | 0.74 | PTGS2 (0.45) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL29245825 | 0.69 | DRD1 (0.32) | KEAP1NFE2L2 | |
| SCHEMBL5030910 | 0.69 | PTGS2 (0.40) | KEAP1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL4299 | 0.69 | — | — | |
| SCHEMBL6930665 | 0.69 | PTGS2 (0.36) | PTGS2PTGS1 | |
| SCHEMBL4928374 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444238-B1 | PROCESS FOR PREPARING DIFLUOROMETHYLENE COMPOUNDS | SATO PHARMA (JP) | 2021-12-08 | — | — | EP | disclosed |
| EP-3444238-A2 | PROCESS FOR PREPARING DIFLUOROMETHYLENE COMPOUNDS | Sato Pharmaceutical Co., Ltd. (JP) | 2019-02-20 | — | — | EP | disclosed |
| EP-2878594-B1 | DIFLUOROMETHYLENE COMPOUND | SATO PHARMA (JP) | 2018-11-28 | — | — | EP | disclosed |
| US-9650380-B2 | Difluoromethylene compound | SATO PHARMACEUTICAL CO., LTD. (JP) | 2017-05-16 | — | — | US | disclosed |
| US-20170044158-A1 | DIFLUOROMETHYLENE COMPOUND | SATO PHARMACEUTICAL CO., LTD. (JP) | 2017-02-16 | — | — | US | disclosed |
| US-9512119-B2 | Difluoromethylene compound | SATO PHARMACEUTICAL CO., LTD. (JP) | 2016-12-06 | — | — | US | disclosed |
| US-9353046-B2 | Method for producing alkylated aromatic amide derivative | MITSUI CHEMICALS AGRO, INC. (JP) | 2016-05-31 | — | — | US | disclosed |
| US-20150191463-A1 | DIFLUOROMETHYLENE COMPOUND | SATO PHARMACEUTICAL CO., LTD. (JP) | 2015-07-09 | — | — | US | disclosed |
| EP-2878594-A1 | DIFLUOROMETHYLENE COMPOUND | Sato Pharmaceutical Co., Ltd. (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-20150065721-A1 | METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE | MITSUI CHEMICALS AGRO, INC. (JP) | 2015-03-05 | — | — | US | disclosed |
| EP-2835366-A1 | METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE | Mitsui Chemicals Agro, Inc. (JP) | 2015-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044158-A1 | DIFLUOROMETHYLENE COMPOUND | XDH, URB2, MNAT1 | KEAP1 367/4885NFE2L2 480/4885PTGS2 3790/4885 |
| US-20150191463-A1 | DIFLUOROMETHYLENE COMPOUND | XDH, SULT1A1, RFT1 | KEAP1 446/4885NFE2L2 560/4885PTGS2 3781/4885 |
| US-20150065721-A1 | METHOD FOR PRODUCING ALKYLATED AROMATIC AMIDE DERIVATIVE | NAT1, HAX1, AOC2 | KEAP1 1322/4885NFE2L2 896/4885PTGS2 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.