Sugi Predict

Sugi Predict / Compounds / SCHEMBL16475201

SCHEMBL16475201

SCHEMBL16475201

COC(=O)c1cc(OC)ncc1Br

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ NNMT P40261 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.44
▸ KDM4E B2RXH2 2/20 0.44
▸ KMT2A Q03164 5/20 0.42
▸ HCRTR1 O43613 2/20 0.41
▸ HCRTR2 O43614 2/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ MAPT P10636 1/20 0.41
▸ HPGD P15428 1/20 0.40
▸ PABPC1 P11940 1/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ PKM P14618 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ SIRT6 Q8N6T7 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ TTBK1 Q5TCY1 1/20 0.38
▸ TTBK2 Q6IQ55 1/20 0.38
▸ TSHR P16473 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19813985 0.86 L3MBTL1 (0.41) L3MBTL1ALDH1A1KDM4EKMT2AMEN1
SCHEMBL24770289 0.85 HCRTR1 (0.42) L3MBTL1ALDH1A1KDM4EKMT2AHCRTR1
SCHEMBL30017651 0.85 HCRTR1 (0.42) L3MBTL1ALDH1A1KDM4EKMT2AHCRTR1
SCHEMBL16701908 0.84 NNMT (0.47) L3MBTL1NNMTALDH1A1KMT2AMEN1
SCHEMBL14916430 0.84 LCK (0.53) L3MBTL1NNMTALDH1A1KDM4EKMT2A
SCHEMBL28822718 0.84 NNMT (0.45) L3MBTL1NNMTALDH1A1KDM4EKMT2A
SCHEMBL15814022 0.84 LMNA (0.40) L3MBTL1KMT2AHCRTR1HCRTR2MEN1
SCHEMBL20522604 0.84 NNMT (0.45) NNMTALDH1A1KDM4EKMT2AMEN1
SCHEMBL30570813 0.84 NNMT (0.54) L3MBTL1NNMTALDH1A1KDM4EKMT2A
SCHEMBL26118926 0.84 NNMT (0.54) L3MBTL1NNMTALDH1A1KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116768861-B SOS1 protein degradation targeting chimeric and composition, preparation and application thereof 北京福元医药股份有限公司 2026-05-12 — — CN disclosed
US-20260049074-A1 THIADIAZOLYL DERIVATIVES IDEAYA BIOSCIENCES, INC. (US) 2026-02-19 — — US disclosed
US-12509454-B2 Thiadiazolyl derivatives IDEAYA BIOSCIENCES, INC. (US) 2025-12-30 — — US disclosed
CN-119912402-A FTO inhibitor and preparation method and application thereof 中国科学院上海药物研究所 2025-05-02 — — CN disclosed
US-20240287080-A1 O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED (GB) 2024-08-29 — — US disclosed
CN-118027018-A Tetrahydrocyclopentyl [ c ] pyrrole methyl ketone derivative, preparation method and application thereof 江苏恩华药业股份有限公司 2024-05-14 — — CN disclosed
EP-4352055-A1 O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS Ideaya Biosciences, Inc. (US) 2024-04-17 — — EP disclosed
CN-117794927-A O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta 伊迪亚生物科学有限公司 2024-03-29 — — CN disclosed
EP-3976608-B1 THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS IDEAYA BIOSCIENCES INC (US) 2023-11-08 — — EP disclosed
EP-3976608-B1 THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS IDEAYA BIOSCIENCES INC (US) 2023-11-08 — — EP disclosed
US-9675593-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2017-06-13 — — US disclosed
US-20170121345-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2017-05-04 — — US disclosed
US-20170121345-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2017-05-04 — — US disclosed
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2016-09-15 — — US disclosed
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2016-09-15 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
US-9359379-B2 Anti-fibrotic pyridinones INTERMUNE, INC. (US) 2016-06-07 — — US disclosed
WO-2015153683-A1 ANTI-FIBROTIC PYRIDINONES INTERMUNE, INC. (US) 2015-10-08 — — WO disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES GENENTECH, INC. 2014-04-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049074-A1 THIADIAZOLYL DERIVATIVES POLH, POLM, POLD1 L3MBTL1 1234/4885NNMT 3568/4885ALDH1A1 2481/4885
US-20140107110-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 L3MBTL1 4144/4885NNMT 191/4885ALDH1A1 529/4885
US-20160263090-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 L3MBTL1 4144/4885NNMT 191/4885ALDH1A1 529/4885
US-20240287080-A1 O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS POLQ, POLK, POLB L3MBTL1 2590/4885NNMT 2015/4885ALDH1A1 2542/4885
US-20170121345-A1 ANTI-FIBROTIC PYRIDINONES MMP1, COL1A1, COL2A1 L3MBTL1 4144/4885NNMT 191/4885ALDH1A1 529/4885
US-12509454-B2 Thiadiazolyl derivatives POLD1, POLQ, DNA2 L3MBTL1 3784/4885NNMT 3724/4885ALDH1A1 1747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.