Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 5/20 | 0.34 |
| ▸ | PKLR | P30613 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PGAM1 | P18669 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9421459 | 0.82 | HTR6 (0.44) | ELANEDRD1POLBSMN1; SMN2HTR6 | |
| SCHEMBL10886678 | 0.81 | HSD17B10 (0.38) | ELANEDRD1POLBSMN1; SMN2HTR6 | |
| SCHEMBL31297149 | 0.81 | HSD17B10 (0.38) | ELANEDRD1POLBSMN1; SMN2HTR6 | |
| SCHEMBL9422448 | 0.79 | CA1 (0.45) | DRD1 | |
| SCHEMBL579428 | 0.79 | ELANE (0.40) | ELANEDRD1SMN1; SMN2MEN1KMT2A | |
| Potassium Ion SCHEMBL6714454 | 0.78 | ALDH1A1 (0.39) | POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4757503 | 0.78 | ALDH1A1 (0.46) | GAAP2RY2 | |
| Alcohol SCHEMBL9948961 | 0.76 | HTR6 (0.51) | POLBSMN1; SMN2HTR6ESR1 | |
| SCHEMBL7267144 | 0.75 | MAPT (0.49) | SMN1; SMN2 | |
| SCHEMBL10450977 | 0.75 | NPC1 (0.36) | ELANEDRD1PKLRSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117004052-B | Viscous conductive hydrogel and preparation method thereof | 上海英科心电图医疗产品有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117004052-A | Viscous conductive hydrogel and preparation method thereof | 上海英科心电图医疗产品有限公司 | 2023-11-07 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |