Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769583 | 0.85 | ELANE (0.41) | ELANEKDM4EHTTALDH1A1KMT2A | |
| SCHEMBL18817856 | 0.84 | ELANE (0.41) | ELANEKDM4EHTTALDH1A1KMT2A | |
| SCHEMBL489857 | 0.82 | ALDH1A1 (0.48) | ELANEKDM4EHTTALDH1A1KMT2A | |
| SCHEMBL15795286 | 0.79 | ELANE (0.40) | ELANEKMT2AL3MBTL1 | |
| Potassium Ion SCHEMBL1649488 | 0.79 | ELANE (0.35) | ELANEKMT2ASMN1; SMN2MEN1DRD1 | |
| SCHEMBL9411578 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1LMNASMN1; SMN2 | |
| Sulfuric Acid SCHEMBL28055088 | 0.74 | DRD2 (0.52) | ELANEALDH1A1KMT2APTK2BLMNA | |
| SCHEMBL579429 | 0.73 | DRD2 (0.40) | ELANEKMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL30149165 | 0.73 | DRD2 (0.57) | ELANEKDM4EHTTALDH1A1KMT2A | |
| SCHEMBL769670 | 0.73 | DRD2 (0.57) | ELANEKDM4EHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7233046-A | — | — | None | — | — | JP | disclosed |
| US-12036306-B2 | Cosmetic product | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2024-07-16 | — | — | US | disclosed |
| US-20240166823-A1 | CROSSLINKED ORGANOSILICON RESIN, A METHOD FOR PRODUCING SAME, AND A COSMETIC | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2024-05-23 | — | — | US | disclosed |
| US-11912828-B2 | Crosslinked organosilicon resin, a method for producing same, and a cosmetic | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2024-02-27 | — | — | US | disclosed |
| CN-117481998-A | Retinol substitutes in skin treatment | 西姆莱斯有限公司 | 2024-02-02 | — | — | CN | disclosed |
| US-11801210-B2 | Retinol replacement in skin treatment | SYMRISE AG (DE) | 2023-10-31 | — | — | US | disclosed |
| US-11642302-B2 | Cosmetic | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2023-05-09 | — | — | US | disclosed |
| EP-3479817-B1 | COSMETIC | SHINETSU CHEMICAL CO (JP) | 2022-05-04 | — | — | EP | disclosed |
| US-20220000756-A1 | COSMETIC PRODUCT | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2022-01-06 | — | — | US | disclosed |
| US-11214652-B2 | Organic group-modified organosilicon resin, production method thereof, and cosmetic | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2022-01-04 | — | — | US | disclosed |
| US-6306915-B1 | OLIGOSACCHARIDES OF URONIC ACID, GLUCOSAMINE, GALACTOSE, AND MANNOSE, OR ONE URONIC ACID; R.SUB.2 IS AN ALKYL GROUP, EMULSIFIER OF THE PRESENT INVENTION HAS MARKED MOISTURIZING EFFECT, SKIN ROUGHENING PREVENTING EFFECT | KIBUN FOOD CHEMIFA CO., LTD (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-0689830-B1 | Skin cosmetic composition | SENJU PHARMA CO (JP) | 2001-09-26 | — | — | EP | disclosed |
| EP-0978274-A2 | Emulsifier and emulsified composition | Kibun Food ChemiFA Co., Ltd. (JP) | 2000-02-09 | — | — | EP | disclosed |
| EP-0976381-A1 | DERMATOLOGIC PREPARATION | SHISEIDO COMPANY LIMITED (JP) | 2000-02-02 | — | — | EP | disclosed |
| US-5750563-A | MIXING A CATECHIN, A FLAVONE, OR A TANNIN INTO EMULSIFIED MIXTURE OF KOJIC ACID, NONIONIC SURFACTANT, AND ULTRAVIOLET LIGHT ABSORBER; STABILIZATION, DISCOLORATION INHIBITION | SANSHO SEIYAKU CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| EP-0826365-A2 | Tocopheryl ascorbyl phosphate-cyclodextrin clathrate and a topical dermal composition containing said clathrate | Senju Pharmaceutical Co., Ltd. (JP) | 1998-03-04 | — | — | EP | disclosed |
| US-5637293-A | STABILITY; DISCOLORATION INHIBITION; MIXTURE OF KOJIC ACID, ULTRAVIOLET RADIATION ABSORBER, FATTY ESTER AND(OR) GLYCERIDE | SANSHO SEIYAKU CO., LTD. (JP) | 1997-06-10 | — | — | US | disclosed |
| US-5599528-A | PREVENTING DISCOLORATION AND DECOMPOSITION OF KOJIC ACID IN AQUEOUS COSMETIC EMULSIONS BY ADDING NONIONIC SURFACTANTS AND CONTROLLING HYDROPHILIC-LIPOPHILIC BALANCE | SANSHO SEIYAKU CO., LTD. (JP) | 1997-02-04 | — | — | US | disclosed |
| EP-0689830-A2 | Skin cosmetic composition | Senju Pharmaceutical Co., Ltd. (JP) | 1996-01-03 | — | — | EP | disclosed |
| JP-H07233046-A | EXTERNAL PREPARATION | KOSE CORP | 1995-09-05 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11801210-B2 | Retinol replacement in skin treatment | RBP1, RBP4, LRAT | ELANE 905/4885KDM4E 2857/4885HTT 4376/4885 |
| US-20240166823-A1 | CROSSLINKED ORGANOSILICON RESIN, A METHOD FOR PRODUCING SAME, AND A COSMETIC | NOTUM, OR10J3, CUTA | ELANE 765/4885KDM4E 1180/4885HTT 704/4885 |
| US-11912828-B2 | Crosslinked organosilicon resin, a method for producing same, and a cosmetic | NOTUM, OR10J3, CUTA | ELANE 765/4885KDM4E 1180/4885HTT 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.