Azosemide

Azosemide

SCHEMBL1649512

NS(=O)(=O)c1cc(-c2nn[nH]n2)c(NCc2cccs2)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PDE4D Q08499 1/20 1.00
▸ PDE3A Q14432 1/20 1.00
▸ CISD1 Q9NZ45 2/20 0.58
▸ APP P05067 1/20 0.55
▸ POLB P06746 1/20 0.42
▸ CA12 O43570 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ CA3 P07451 1/20 0.39
▸ CA6 P23280 1/20 0.39
▸ CA5A P35218 1/20 0.39
▸ CA7 P43166 1/20 0.39
▸ CA9 Q16790 1/20 0.39
▸ CA13 Q8N1Q1 1/20 0.39
▸ CA14 Q9ULX7 1/20 0.39
▸ CA5B Q9Y2D0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azosemide SCHEMBL30754398 0.82 PDE4D (0.70) PDE4DPDE3ACISD1APPPOLB
Azosemide SCHEMBL48976 0.82 PDE4D (0.70) PDE4DPDE3ACISD1APPPOLB
Azosemide SCHEMBL4421865 0.82 PDE4D (0.70) PDE4DPDE3ACISD1APPPOLB
Azosemide SCHEMBL8988688 0.82 PDE4D (0.69) PDE4DPDE3ACISD1APPPOLB
SCHEMBL18993721 0.77 PDE4D (0.62) PDE4DPDE3ACISD1POLBCA12
Azosemide SCHEMBL230626 0.77 PDE4D (0.62) PDE4DPDE3ACISD1APPPOLB
SCHEMBL231240 0.76 PDE4D (0.61) PDE4DPDE3ACISD1POLBCA12
SCHEMBL18993718 0.74 PDE4D (0.59) PDE4DPDE3ACISD1POLBCA12
Azosemide SCHEMBL231405 0.74 PDE4D (0.58) PDE4DPDE3ACISD1APPPOLB
SCHEMBL1714459 0.74 CISD1 (1.00) PDE4DPDE3ACISD1APPPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118754869-A Preparation method and application of high-purity methane disulfonic acid methylene ester capable of reducing three wastes 联泓(江苏)新材料研究院有限公司 2024-10-11 — — CN claimed
US-20230382838-A1 PROCESS FOR THE PREPARATION OF CANNABIDIOL AESICA PHARMACEUTICALS LIMITED (GB) 2023-11-30 — — US claimed
CN-116143373-A Chicken manure steam explosion pretreatment machine 巴州友质种业有限公司 2023-05-23 — — CN claimed
US-12625441-B2 Electrostatic charge image developing toner and image forming method Konica Minolta, Inc. (JP) 2026-05-12 — — US disclosed
EP-3431488-B1 METHOD FOR PRODUCING CRYSTAL OF REDUCED GLUTATHIONE KYOWA HAKKO BIO CO LTD (JP) 2026-05-06 — — EP disclosed
US-12619152-B2 Method for producing actinic ray-sensitive or radiation-sensitive resin composition, pattern forming method, method for producing electronic device, and method for producing onium salt FUJIFILM CORPORATION (JP) 2026-05-05 — — US disclosed
US-12601992-B2 Developing roller, process cartridge, electrophotographic image forming apparatus, and electrophotographic image forming system Konica Minolta, Inc. (JP) 2026-04-14 — — US disclosed
EP-2838129-B1 COMPOSITION FOR ORGANIC ELECTROLUMINESCENT ELEMENTS MITSUBISHI CHEM CORP (JP) 2026-03-18 — — EP disclosed
US-20260049264-A1 CHEMICAL SOLUTION AND CHEMICAL SOLUTION-HOUSING ARTICLE FUJIFILM CORP (JP) 2026-02-19 — — US disclosed
US-20260042089-A1 METHOD FOR PRODUCING CATION EXCHANGE RESIN AND METHOD FOR REFINING ORGANIC ACID SOLUTION ORGANO CORPORATION (JP) 2026-02-12 — — US disclosed
EP-4656713-A1 CELL AGGREGATE DISSOCIATING AGENT AJINOMOTO CO., INC. (JP) 2025-12-03 — — EP disclosed
US-20060134198-A1 Pharmaceutical compositions with improved dissolution JOHNSON & JOHNSON CONSUMER INC. 2006-06-22 — — US disclosed
US-20060052432-A1 Pharmaceutical compositions with improved dissolution TRANSFORM PHARMACEUTICALS, INC. 2006-03-09 — — US disclosed
EP-1579198-A1 PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION Transform Pharmaceuticals, Inc. (US) 2005-09-28 — — EP disclosed
CN-1668283-A Pharmaceutical composition with improved dissolution TRANSFORM PHARMACEUTICALS INC (US) 2005-09-14 — — CN disclosed
EP-1515703-A1 PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION Transform Pharmaceuticals, Inc. (US) 2005-03-23 — — EP disclosed
US-20050025791-A1 Pharmaceutical compositions with improved dissolution TRANSFORM PHARMACEUTICALS, INC. 2005-02-03 — — US disclosed
WO-2004061433-A1 PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION TRANSFORM PHARMACEUTICALS, INC. (US) 2004-07-22 — — WO disclosed
WO-2004026235-A2 PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION TRANSFORM PHARMACEUTICALS, INC. (US) 2004-04-01 — — WO disclosed
WO-2004000284-A1 PHARMACEUTICAL COMPOSITIONS WITH IMPROVED DISSOLUTION TRANSFORM PHARMACEUTICALS, INC. (US) 2003-12-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049264-A1 CHEMICAL SOLUTION AND CHEMICAL SOLUTION-HOUSING ARTICLE OR10J3, PPM1D, PPM1F PDE4D 3170/4885PDE3A 3025/4885CISD1 2128/4885
US-20050025791-A1 Pharmaceutical compositions with improved dissolution ABCG2, SI, SLC10A2 PDE4D 1755/4885PDE3A 744/4885CISD1 3478/4885
US-12619152-B2 Method for producing actinic ray-sensitive or radiation-sensitive resin composition, pattern forming method, method for producing electronic device, and method for producing onium salt ROCK2, ROCK1, SLC9A5 PDE4D 1568/4885PDE3A 1751/4885CISD1 3145/4885
US-20230382838-A1 PROCESS FOR THE PREPARATION OF CANNABIDIOL CNR2, CNR1, C1R PDE4D 4782/4885PDE3A 4781/4885CISD1 866/4885
US-20060052432-A1 Pharmaceutical compositions with improved dissolution ABCG2, SI, SLC10A2 PDE4D 1868/4885PDE3A 616/4885CISD1 3219/4885
US-20260042089-A1 METHOD FOR PRODUCING CATION EXCHANGE RESIN AND METHOD FOR REFINING ORGANIC ACID SOLUTION ME1, SLC25A11, SLC7A1 PDE4D 4885/4885PDE3A 4830/4885CISD1 1604/4885
US-20060134198-A1 Pharmaceutical compositions with improved dissolution ABCG2, SI, SLC10A2 PDE4D 1868/4885PDE3A 616/4885CISD1 3219/4885
US-12601992-B2 Developing roller, process cartridge, electrophotographic image forming apparatus, and electrophotographic image forming system MARK4, MAP1LC3B, MAP1LC3A PDE4D 3358/4885PDE3A 4858/4885CISD1 3050/4885
US-12625441-B2 Electrostatic charge image developing toner and image forming method EWSR1, AFF4, DYRK2 PDE4D 2009/4885PDE3A 2610/4885CISD1 1439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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