Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Clorprenaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.90 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.90 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 0.46 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clorprenaline SCHEMBL15568417 | 0.95 | ADRB2 (0.93) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL45370 | 0.95 | ADRB2 (0.93) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL29417577 | 0.95 | ADRB2 (0.93) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL29483933 | 0.95 | ADRB2 (1.00) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL250611 | 0.95 | ADRB2 (1.00) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL2852860 | 0.94 | ADRB2 (0.90) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL406791 | 0.93 | ADRB2 (0.97) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL30394245 | 0.93 | ADRB2 (0.97) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL2852861 | 0.92 | ADRB2 (0.93) | ADRB2ADRB1HIF1ACYP2D6NFKB1 | |
| Clorprenaline SCHEMBL122700 | 0.88 | ADRB2 (0.85) | ADRB2ADRB1HIF1ACYP2D6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1739600-A | Chinese medicine prepn for treating respiratory tract diseases and its prepn process and quality control method | WANG HENGXIN (CN) | 2006-03-01 | — | — | CN | claimed |
| CN-1362231-A | Nano Haizhu Chuanxiding medicine and its preparation | YANG MENGJUN (CN) | 2002-08-07 | — | — | CN | claimed |
| CN-117825550-A | Method for determining beta-receptor agonist drugs in veterinary drug preparation | 石家庄海关技术中心 | 2024-04-05 | — | — | CN | disclosed |
| US-10859587-B2 | Application of artificially expressed HSP27 protein in detecting a residue of a β2-adrenergic receptor agonist-based drug | Henan Academy of Agricultural Science (CN) | 2020-12-08 | — | — | US | disclosed |
| US-20190277867-A1 | APPLICATION OF ARTIFICIALLY EXPRESSED HSP27 PROTEIN IN DETECTING RESIDUE OF A ß2-ADRENERGIC RECEPTOR AGONIST BASED DRUG | Henan Academy of Agricultural Science (CN) | 2019-09-12 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| CN-1739600-A | Chinese medicine prepn for treating respiratory tract diseases and its prepn process and quality control method | WANG HENGXIN (CN) | 2006-03-01 | — | — | CN | disclosed |
| CN-1362231-A | Nano Haizhu Chuanxiding medicine and its preparation | YANG MENGJUN (CN) | 2002-08-07 | — | — | CN | disclosed |