Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Clorprenaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.93 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.93 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clorprenaline SCHEMBL15568417 | 1.00 | ADRB2 (0.93) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL29417577 | 1.00 | ADRB2 (0.93) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL2852860 | 0.98 | ADRB2 (0.90) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL406791 | 0.98 | ADRB2 (0.97) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL30394245 | 0.98 | ADRB2 (0.97) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL2852861 | 0.97 | ADRB2 (0.93) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL29483933 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL250611 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL1650012 | 0.95 | ADRB2 (0.90) | ADRB2ADRB1BLMCYP2D6HIF1A | |
| Clorprenaline SCHEMBL122700 | 0.89 | ADRB2 (0.85) | ADRB2ADRB1BLMCYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 23564 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260033991-A1 | METHODS AND PROBES FOR INTRASCLERAL LASER SURGERY | IRIDEX CORPORATION (US) | 2026-02-05 | — | — | US | claimed |
| CN-120041328-A | Bacillus bailii BJ-1141 and application thereof in preventing and controlling plant diseases | 北京市农林科学院 | 2025-05-27 | — | — | CN | claimed |
| CN-119775243-A | Compound geigera alkyd A prepared by co-culturing medicinal fungus geigera mao and geigera brown, and preparation method and application thereof | 中南民族大学 | 2025-04-08 | — | — | CN | claimed |
| CN-119546623-A | Compositions and methods for somatic embryogenesis in dicotyledonous plants | 先锋国际良种公司 | 2025-02-28 | — | — | CN | claimed |
| CN-119331927-A | Method for synthesizing glycine by catalyzing oxalic acid with multiple enzymes in vitro | 中国科学院天津工业生物技术研究所 | 2025-01-21 | — | — | CN | claimed |
| CN-118973395-A | Methods and compositions for controlling pests on perennial plants | 环球化学股份有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118931677-A | Black bean wine and preparation method thereof | 黑龙江吕家烧锅酒业有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-116240196-B | Mutant of phosphatase and application of mutant in preparation of fructose and psicose | 中国科学院天津工业生物技术研究所 | 2024-11-01 | — | — | CN | claimed |
| EP-2612551-B2 | Mite composition comprising a predatory mite and immobilized prey contacted with a fungus reducing agent and methods and uses related to the use of said composition | KOPPERT BV (NL) | 2024-10-16 | — | — | EP | claimed |
| CN-118574510-A | Predatory mites with improved traits | 生物蜜蜂赛德利亚胡有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-1070821-A | A kind of production method of bueaty agent-return to children's looks frostlike powder | QINCUN PAN (CN) | 1993-04-14 | — | — | CN | claimed |
| US-5192677-A | Alkali and heat stable protease from thermomonospora fusca | CORNELL RESEARCH FOUNDATION INC. (US) | 1993-03-09 | — | — | US | claimed |
| CN-1067377-A | Formica fusca extract and preparation thereof | WEN YUANKAI (CN) | 1992-12-30 | — | — | CN | claimed |
| EP-0489104-A1 | PROCESS FOR TREATMENT OF LIGNOCELLULOSIC PULP. | NOVO NORDISK AS (DK) | 1992-06-10 | — | — | EP | claimed |
| EP-0473545-A2 | Thermostable endoxylanases | SANDOZ LTD. (CH) | 1992-03-04 | — | — | EP | claimed |
| WO-1991002839-A1 | PROCESS FOR TREATMENT OF LIGNOCELLULOSIC PULP | NOVO NORDISK A/S (DK) | 1991-03-07 | — | — | WO | claimed |
| CN-1047807-A | Method and apparatus for microwave sterilization of sealed bottles | EISAI CO LTD (JP) | 1990-12-19 | — | — | CN | claimed |
| CN-1041102-A | MULTIFUNCTIONAL HEALTH CARE PERFUME | LI SHENGMEI (CN) | 1990-04-11 | — | — | CN | claimed |
| CN-1034842-A | A method for producing algae with improved biological effect | CAOLA KOZMETIKAI (HU) | 1989-08-23 | — | — | CN | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |