Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.40 |
| ▸ | CCR8 | P51685 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502605 | 0.84 | ALOX15 (0.56) | LMNAHTTMAPTKDM4EALOX15 | |
| SCHEMBL7920176 | 0.78 | CCR1 (0.46) | LMNACCR1CCR5CCR8HTT | |
| SCHEMBL16502608 | 0.78 | SLC40A1 (0.50) | LMNACCR1CCR5CCR8HTT | |
| SCHEMBL7919762 | 0.76 | KDM4E (0.34) | LMNAMAPTKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL16503574 | 0.74 | GABRG2 (0.33) | MAPTKDM4ETP53HSP90AA1SMN1; SMN2 | |
| SCHEMBL7916651 | 0.72 | TUBB4A (0.38) | KDM4EMEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL16502784 | 0.72 | SLC9A1 (0.48) | — | |
| SCHEMBL16502512 | 0.70 | ALOX15 (0.54) | HTTMAPTKDM4EALOX15TP53 | |
| SCHEMBL7916645 | 0.70 | HDAC6 (0.42) | LMNAHTTMAPTALOX15HDAC3 | |
| SCHEMBL16502596 | 0.70 | ALOX15 (0.61) | HTTMAPTKDM4EALOX15TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |