SCHEMBL1650892

SCHEMBL1650892

O=C(O)C1=CN2CC=Cc3cccc(c32)C1

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
TRPA1 O75762 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL10588716 0.99 MAOA (0.34) MAOAMAOB
SCHEMBL9680591 0.87 TRPA1 (0.32) TRPA1
Arginine SCHEMBL6240955 0.78 OTC (0.32)
SCHEMBL7210084 0.77
SCHEMBL9032487 0.73 MAOA (0.31) MAOAMAOB
SCHEMBL6780552 0.73 TRPA1 (0.35) TRPA1
SCHEMBL11724902 0.73 SRD5A2 (0.34)
SCHEMBL11202182 0.73 NOTUM (0.39)
Hydrochloric Acid SCHEMBL9223535 0.72 PARP1 (0.31) MAOAMAOB
Hydrochloric Acid SCHEMBL10432400 0.72 NOTUM (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3344262-A1 IMMUNE CELLS HAVING INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE OF THE SAME Innate Tumor Immunity, Inc. (US) 2018-07-11 EP claimed
WO-2017040670-A1 IMMUNE CELLS HAVING INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE OF THE SAME IFM THERAPEUTICS, INC (US) 2017-03-09 WO claimed
US-20170056448-A1 IMMUNE CELLS HAVING INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE OF THE SAME IFM THERAPEUTICS, INC (US) 2017-03-02 US claimed
EP-0203795-B1 Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same TOKYO TANABE COMPANY LIMITED (JP) 1992-07-29 EP claimed
US-4720495-A Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection TOKYO TANABE CO. LIMITED (JP) 1988-01-19 US claimed
EP-0203795-A2 Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same TOKYO TANABE COMPANY LIMITED (JP) 1986-12-03 EP claimed
JP-56055389-A None JP disclosed
JP-63192753-A None JP disclosed
JP-55118485-A None JP disclosed
JP-57193459-A None JP disclosed
EP-3922279-A1 DRUG DELIVERY COMPOSITIONS AND USES THEREOF Dana Farber Cancer Institute, Inc. (US) 2021-12-15 EP disclosed
US-20210246211-A1 DRUG DELIVERY COMPOSITIONS AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-08-12 US disclosed
US-11021539-B2 Drug delivery compositions and uses thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2021-06-01 US disclosed
US-4443447-A Phenyl-substituted tricyclic antibacterial agents RIKER LABORATORIES, INC. (US) 1984-04-17 US disclosed
US-4404207-A Antimicrobial 8-substituted benzo [IJ]quinolizines RIKER LABORATORIES, INC. (US) 1983-09-13 US disclosed
JP-S57193459-A QUINOLINE DERIVATIVE OTSUKA PHARMACEUT CO LTD 1982-11-27 JP disclosed
JP-S5655389-A BENZO IJ QUINOLIDINE-2-CARBOXYLIC ACID DERIVATIVE, AND ITS PREPARATION OTSUKA PHARMACEUT CO LTD 1981-05-15 JP disclosed
JP-S55118485-A BENZO IJ QUINOLIZINE-2-CARBOXYLIC ACID DERIVATIVE OTSUKA PHARMACEUT CO LTD 1980-09-11 JP disclosed
US-4014877-A MICROBIOCIDES RIKER LABORATORIES, INC. (US) 1977-03-29 US disclosed
US-3985882-A ADMISTERING RIKER LABORATORIES, INC. (US) 1976-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170056448-A1 IMMUNE CELLS HAVING INCREASED IMMUNITY OR RESISTANCE TO AN IMMUNOSUPPRESSIVE CYTOKINE AND USE OF THE SAME IL2, IFNG, IL2RA MAOA 4789/4885MAOB 4818/4885TRPA1 4740/4885
US-20210246211-A1 DRUG DELIVERY COMPOSITIONS AND USES THEREOF STING1, IL15, IL15RA MAOA 3782/4885MAOB 4477/4885TRPA1 2840/4885
US-11021539-B2 Drug delivery compositions and uses thereof STING1, IL15, IL15RA MAOA 3782/4885MAOB 4477/4885TRPA1 2840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.