Sugi Predict

Sugi Predict / Compounds / SCHEMBL165384

SCHEMBL165384

SCHEMBL165384

CCS(=O)(=O)c1ccc(CC(=O)O)cc1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PSIP1 O75475 2/20 0.57
▸ RORC P51449 9/20 0.55
▸ ALDH1A1 P00352 2/20 0.53
▸ HPGD P15428 1/20 0.53
▸ HSD17B10 Q99714 1/20 0.53
▸ CA2 P00918 1/20 0.52
▸ CAMK2A Q9UQM7 1/20 0.52
▸ AKR1B1 P15121 1/20 0.50
▸ MEP1B Q16820 1/20 0.50
▸ GAA P10253 2/20 0.48
▸ ABCC4 O15439 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ PTGS1 P23219 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ PTGDR2 Q9Y5Y4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL165901 0.87 ALDH1A1 (0.58) RORCALDH1A1HPGDHSD17B10CA2
SCHEMBL16892297 0.84 PSIP1 (0.57) PSIP1RORCALDH1A1GAA
SCHEMBL23193744 0.84 ALDH1A1 (0.64) RORCALDH1A1HPGDHSD17B10CA2
SCHEMBL14744518 0.82 PSIP1 (0.55) PSIP1RORCGAA
SCHEMBL16799135 0.82 PSIP1 (0.60) PSIP1RORCALDH1A1CA2GAA
SCHEMBL16799869 0.82 CA2 (0.46) RORCALDH1A1HPGDHSD17B10CA2
SCHEMBL8052632 0.82 PTGDR2 (0.54) ALDH1A1HPGDHSD17B10CA2CAMK2A
SCHEMBL168163 0.82 PTGDR2 (0.54) ALDH1A1HPGDHSD17B10CA2CAMK2A
SCHEMBL14744565 0.81 ALDH1A1 (0.66) PSIP1ALDH1A1CA2GAALMNA
SCHEMBL10061269 0.81 CA2 (0.56) ALDH1A1HPGDHSD17B10CA2CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332155-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS AURIGENE ONCOLOGY LTD (IN) 2025-10-30 — — US disclosed
US-12377088-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators AURIGENE ONCOLOGY LIMITED (IN) 2025-08-05 — — US disclosed
CN-113072546-B Five-membered heteroaromatic derivative and preparation method and application thereof 广东东阳光药业股份有限公司 2025-05-30 — — CN disclosed
CN-113912563-B Benzo five-membered nitrogen heterocyclic compound and application thereof 中国科学院广州生物医药与健康研究院 2025-05-27 — — CN disclosed
US-12297164-B2 Benzidine compound and application thereof GUANGZHOU IMD THERAPEUTICS CO., LTD. (CN) 2025-05-13 — — US disclosed
CN-116874370-B Carnosic acid derivative and preparation method and application thereof 山东省药学科学院 2025-03-18 — — CN disclosed
US-12187684-B2 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical use thereof JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2025-01-07 — — US disclosed
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2024-09-26 — — US disclosed
CN-113072476-B ROR gamma t inhibitor and preparation method and application thereof 广东东阳光药业股份有限公司 2024-05-14 — — CN disclosed
CN-113302185-B Benzofuran-6-carboxamide derivatives, preparation method and pharmaceutical application thereof 上海和誉生物医药科技有限公司 2024-04-09 — — CN disclosed
WO-2012100734-A1 COMPOUNDS USEFUL AS RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS GLAXO GROUP LIMITED (GB) 2012-08-02 — — WO disclosed
WO-2012028100-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 — — WO disclosed
WO-2012028100-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 — — WO disclosed
WO-2012027965-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 — — WO disclosed
WO-2012027965-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 — — WO disclosed
EP-2168962-A2 PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE MODULATORS Prosidion Limited (GB) 2010-03-31 — — EP disclosed
US-7214681-B2 Tri(cyclo) substituted amide compounds PROSIDION LIMITED (GB) 2007-05-08 — — US disclosed
EP-1594867-A2 PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE MODULATORS Prosidion Limited (GB) 2005-11-16 — — EP disclosed
US-20040181067-A1 Tri(cyclo) substituted amide compounds OSI PHARMACEUTICALS, INC. 2004-09-16 — — US disclosed
WO-2004072031-A2 PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE MODULATORS PROSIDION LIMITED (GB) 2004-08-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12377088-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators RORC, RORA, RORB PSIP1 3334/4885RORC 1/4885ALDH1A1 235/4885
US-20250332155-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS RORC, RORA, RORB PSIP1 3334/4885RORC 1/4885ALDH1A1 235/4885
US-20040181067-A1 Tri(cyclo) substituted amide compounds GPR119, IAPP, SLC5A1 PSIP1 3148/4885RORC 1406/4885ALDH1A1 1595/4885
US-12297164-B2 Benzidine compound and application thereof RORC, RORB, RORA PSIP1 2937/4885RORC 1/4885ALDH1A1 406/4885
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF RORC, RORB, RORA PSIP1 1137/4885RORC 1/4885ALDH1A1 1160/4885
US-12187684-B2 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORγ) and pharmaceutical use thereof RORC, RORB, RORA PSIP1 3768/4885RORC 1/4885ALDH1A1 244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.