Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Nitrophenolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.48 |
| ▸ | CXCR2 known ✓ | P25025 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.63 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrophenolate SCHEMBL28029048 | 0.98 | GPR35 (0.65) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL26026 | 0.98 | GPR35 (0.65) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL29360402 | 0.98 | GPR35 (0.65) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL29051225 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL31063576 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL28775726 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL11344901 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL325409 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL10996867 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 | |
| Nitrophenolate SCHEMBL10496084 | 0.95 | GPR35 (0.63) | GPR35CTSBHSD17B10ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118791717-A | Polyether ester-based thermoplastic elastomer and preparation method thereof | 大连理工大学 | 2024-10-18 | — | — | CN | claimed |
| CN-115838453-A | High-molecular heteronuclear porphyrin complex and preparation method and application thereof | 中国科学院长春应用化学研究所 | 2023-03-24 | — | — | CN | claimed |
| US-11608416-B2 | Method for synthesizing aliphatic polyester block copolymer regulated by carbon monoxide | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-03-21 | — | — | US | claimed |
| CN-115779962-A | Bi-component organic catalytic system consisting of hydrogen bond donor-nucleophilic bifunctional reagent and organic boron reagent and application thereof | 浙江大学 | 2023-03-14 | — | — | CN | claimed |
| CN-115746034-A | Three-function organic catalyst, preparation method and application thereof | 浙江大学 | 2023-03-07 | — | — | CN | claimed |
| WO-2022257351-A1 | POLYDISULFIDE MATERIAL HAVING EXCELLENT OPTICAL PROPERTIES AND PREPARATION METHOD THEREFOR | 大连理工大学 | 2022-12-15 | — | — | WO | claimed |
| US-20220332901-A1 | METHOD FOR SYNTHESIZING ALIPHATIC POLYESTER BLOCK COPOLYMER REGULATED BY CARBON MONOXIDE | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2022-10-20 | — | — | US | claimed |
| CN-113461926-B | Chemical synthesis method of poly beta-hydroxy fatty acid ester | 大连理工大学 | 2022-08-02 | — | — | CN | claimed |
| CN-111944148-B | High-optical-property degradable polycarbonate and preparation method thereof | 大连理工大学 | 2022-05-17 | — | — | CN | claimed |
| CN-113307973-B | Poly disulfide material with excellent optical performance and preparation method thereof | 大连理工大学 | 2022-04-12 | — | — | CN | claimed |
| CN-109456471-A | A kind of method of simultaneously synthesizing chiral polyester and the chiral end position epoxyalkane of reservation | 大连理工大学 | 2019-03-12 | — | — | CN | claimed |
| CN-107353400-B | A kind of preparation method of polypropylene carbonate/Cellulose nanocrystal composite material | 华中科技大学 | 2019-02-01 | — | — | CN | claimed |
| CN-108559083-A | A kind of preparation method of crystallinity Polythiocarbonate | 大连理工大学 | 2018-09-21 | — | — | CN | claimed |
| CN-106117532-B | A kind of synthetic method and bimetallic catalyst of stereoregularity polyester | 大连理工大学 | 2018-05-08 | — | — | CN | claimed |
| CN-107353400-A | A kind of preparation method of polypropylene carbonate/Cellulose nanocrystal composite | 华中科技大学 | 2017-11-17 | — | — | CN | claimed |
| CN-107226903-A | A kind of the difunctional of synthesis of chiral glycol, bimetallic catalyst and its application | 沈阳金久奇科技有限公司 | 2017-10-03 | — | — | CN | claimed |
| CN-107082885-A | A kind of amino modified polypropylene carbonate of POSS bases and preparation method thereof | 华中科技大学 | 2017-08-22 | — | — | CN | claimed |
| CN-106957452-A | A kind of polyurethane plasticizer, its preparation method and application | 华中科技大学 | 2017-07-18 | — | — | CN | claimed |
| CN-104226366-B | Titanium series catalyst and its preparation method and application | 中国科学院长春应用化学研究所 | 2017-06-06 | — | — | CN | claimed |
| CN-104226366-A | Titanium catalyst as well as preparation method and application of titanium catalyst | CHANGCHUN APPLIED CHEMISTRY | 2014-12-24 | — | — | CN | claimed |