SCHEMBL645757

SCHEMBL645757

O=C(Cl)c1ccc(Cl)cc1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
ALOX15 P16050 1/20 0.54
SMN1; SMN2 Q16637 3/20 0.47
TSHR P16473 1/20 0.47
CASP1 P29466 1/20 0.47
CYP11B2 P19099 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MAPT P10636 1/20 0.46
CYP11B1 P15538 1/20 0.44
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
MAOB P27338 1/20 0.43
MAPK1 P28482 1/20 0.42
HIF1A Q16665 1/20 0.42
TP53 P04637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL284068 0.84 ALDH1A1 (0.56) ALDH1A1ALOX15SMN1; SMN2TSHRCASP1
SCHEMBL27442149 0.84 SMN1; SMN2 (0.48) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL30349584 0.84 ALDH1A1 (0.56) ALDH1A1ALOX15SMN1; SMN2TSHRCASP1
SCHEMBL392840 0.83 SMN1; SMN2 (0.63) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL29392929 0.81 MAOB (0.58) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL325429 0.81 MAOB (0.58) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL911253 0.81 DGAT1 (0.60) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL8162477 0.81 SMN1; SMN2 (0.46) ALDH1A1SMN1; SMN2TSHRCASP1CYP11B2
SCHEMBL20447645 0.80 KDM4E (0.68) ALDH1A1SMN1; SMN2CYP11B2KDM4EMAPT
SCHEMBL165619 0.80 CES2 (0.68) ALDH1A1ALOX15KDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110818556-A Method for producing high-purity 2-chloro-6-fluorobenzoyl chloride by using waste residues 浙江大洋生物科技集团股份有限公司 2020-02-21 CN claimed
US-20260132123-A1 ABAD INHIBITOR COMPOUNDS UNIV COURT OF THE UNIV OF ST ANDREWS (GB) 2026-05-14 US disclosed
US-20260116881-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE IAMBIC THERAPEUTICS INC (US) 2026-04-30 US disclosed
WO-2025122545-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION (US) 2025-06-12 WO disclosed
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS INCYTE CORPORATION 2025-06-05 US disclosed
US-20250136586-A1 Substituted 7-(Pyrimidin-4-yl)Quinolin-4(1H)-One Compounds as Cyclin Dependent Kinase Inhibitors BEIGENE, LTD. (KY) 2025-05-01 US disclosed
WO-2025081019-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE IAMBIC THERAPEUTICS, INC. (US) 2025-04-17 WO disclosed
EP-4514797-A1 SUBSTITUTED 7- (PYRIMIDIN-4-YL) QUINOLIN-4 (1H) -ONE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS BeiGene, Ltd. (KY) 2025-03-05 EP disclosed
CN-119053598-A Substituted 7- (pyrimidin-4-yl) quinolin-4 (1H) -one compounds as cyclin dependent kinase inhibitors 百济神州有限公司 2024-11-29 CN disclosed
EP-4392412-A1 ABAD INHIBITOR COMPOUNDS University Court of The University of St Andrews (GB) 2024-07-03 EP disclosed
CN-1046835-A Go out and remove the method for rice insect pest ROHM & HAAS (US) 1990-11-14 CN disclosed
EP-0317226-A2 Aromatic compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-05-24 EP disclosed
US-4728662-A DIURETICS, URICOSURICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1988-03-01 US disclosed
US-4704483-A FLUORINATION WITH POTASSIUM FLUORIDE OCCIDENTAL CHEMICAL CORPORATION (US) 1987-11-03 US disclosed
US-4673746-A DIURETICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1987-06-16 US disclosed
US-4582948-A VAPOR PHASE CHLORO-DENITRATION REACTION OCCIDENTAL CHEMICAL CORPORATION (US) 1986-04-15 US disclosed
EP-0159388-A2 Preparation of nuclear chlorinated compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1985-10-30 EP disclosed
US-4470930-A Preparation of nuclear chlorinated aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1984-09-11 US disclosed
EP-0002666-B1 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-17 EP disclosed
EP-0002666-A1 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260116881-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE KIF2C, KIF5B, KIF5C ALDH1A1 2556/4885ALOX15 4823/4885SMN1; SMN2 218/4885
US-20260132123-A1 ABAD INHIBITOR COMPOUNDS ADH1C, ADH1A, CBR1 ALDH1A1 52/4885ALOX15 753/4885SMN1; SMN2 2246/4885
US-20250136586-A1 Substituted 7-(Pyrimidin-4-yl)Quinolin-4(1H)-One Compounds as Cyclin Dependent Kinase Inhibitors CDK4, CDK7, CDK8 ALDH1A1 2255/4885ALOX15 4316/4885SMN1; SMN2 3142/4885
US-20250179083-A1 TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS DGKA, DGKI, DGKG ALDH1A1 4279/4885ALOX15 2060/4885SMN1; SMN2 4775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.