SCHEMBL165874

SCHEMBL165874

N#Cc1cc(F)cnc1Cl

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
NPSR1 Q6W5P4 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
KHK P50053 1/20 0.47
CYP11B2 P19099 7/20 0.41
CYP11B1 P15538 4/20 0.39
CSNK1A1 P48729 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
CYP1A2 P05177 3/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP3A4 P08684 1/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
GRM5 P41594 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30063067 1.00 ALDH1A1 (0.53) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL30681117 0.78 ALDH1A1 (0.56) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL1031743 0.78 ALDH1A1 (0.56) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL7216099 0.77 ALDH1A1 (0.55) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL30681150 0.77 ALDH1A1 (0.55) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL25302869 0.75 CHRNB2 (0.40) CYP11B2CYP11B1GRM5
SCHEMBL1164261 0.75 ALDH1A1 (0.53) ALDH1A1NPSR1TDP1KHKCYP11B2
SCHEMBL921763 0.75 KHK (0.43) ALDH1A1KHKCYP11B2CYP11B1CSNK1A1
SCHEMBL13082590 0.75 CHRNB2 (0.40) CYP11B2CYP11B1CYP1A2CYP2C9CYP2C19
SCHEMBL2698043 0.75 ALDH1A1 (0.53) ALDH1A1NPSR1TDP1KHKCYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 472 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116239593-B Preparation method of vitamin Li Xigu intermediate 上海裕兰生物科技有限公司 2025-05-02 CN claimed
CN-117700412-A Impurity of Anrad Wei Gongyi and preparation and detection methods thereof 广东众生睿创生物科技有限公司 2024-03-15 CN claimed
CN-116239593-A Preparation method of vitamin Li Xigu intermediate 上海裕兰生物科技有限公司 2023-06-09 CN claimed
CN-103012257-A Quinolone intermediate synthesis technology Sheng yinuo 2013-04-03 CN claimed
CN-1003236-B Preparation method of 6, 7-disubstituted-1-cyclopropyl-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid 拜尔公司 1989-02-08 CN claimed
EP-4746972-A1 DEUTERATED PARP1 INHIBITOR COMPOUNDS Duke Street Bio Limited (GB) 2026-05-27 EP disclosed
US-20260091048-A1 GIP RECEPTOR AGONIST COMPOUNDS LILLY CO ELI (US) 2026-04-02 US disclosed
US-12508268-B2 Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy AUCKLAND UNISERVICES LIMITED (NZ) 2025-12-30 US disclosed
EP-3820860-B1 PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 LIEBER INST INC (US) 2025-10-15 EP disclosed
US-20250223280-A1 POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS AVILAR THERAPEUTICS, INC. (US) 2025-07-10 US disclosed
US-12312340-B2 Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins AVILAR THERAPEUTICS, INC. (US) 2025-05-27 US disclosed
US-12297208-B2 Small molecule inhibitors of KRAS G12C mutant MERCK SHARP & DOHME LLC (US) 2025-05-13 US disclosed
US-20060052374-A1 Amino-tetrazole analogues and methods of use ABBVIE INC. 2006-03-09 US disclosed
EP-1626045-A1 PROCESSES FOR PRODUCING 3-SUBSTITUTED 2-CHLORO-5-FLUOROPYRIDINE OR SALT THEREOF Asahi Glass Company, Limited (JP) 2006-02-15 EP disclosed
EP-1625123-A2 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS Merck & Co., Inc. (US) 2006-02-15 EP disclosed
WO-2005111003-A1 AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE ABBOTT LABORATORIES (US) 2005-11-24 WO disclosed
CN-1613849-A Preparation of 2-Cl-5-F-nicotinate and nicotonic acid YAOMING KANGDE MEDICINE DEVELO (CN) 2005-05-11 CN disclosed
CN-1571771-A Process for preparing beta-ketoester compound LG LIFE SCIENCES LTD (KR) 2005-01-26 CN disclosed
WO-2004103279-A2 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS MERCK & CO., INC. (US) 2004-12-02 WO disclosed
CN-86100126-A 6, the two replacement-1-cyclopropyl of 7--1,4 dihydro-4-oxo-1, the preparation method and the application thereof of 8-naphthyridines-3-carboxylic acid 1986-07-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12312340-B2 Potent ASGPR-binding compounds for the degradation of immunoglobulins and other proteins ASGR1, FCGR2A, FCGR3B ALDH1A1 3256/4885NPSR1 499/4885TDP1 3940/4885
US-12297208-B2 Small molecule inhibitors of KRAS G12C mutant KRAS, NRAS, HRAS ALDH1A1 4287/4885NPSR1 4407/4885TDP1 3874/4885
US-12508268-B2 Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy IDO1, IDO2, TDO2 ALDH1A1 732/4885NPSR1 223/4885TDP1 841/4885
US-20250223280-A1 POTENT ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF IMMUNOGLOBULINS AND OTHER PROTEINS ASGR1, FCGR2A, FCGR3B ALDH1A1 3256/4885NPSR1 499/4885TDP1 3940/4885
US-20260091048-A1 GIP RECEPTOR AGONIST COMPOUNDS GIPR, GLP1R, GPR119 ALDH1A1 3578/4885NPSR1 109/4885TDP1 4683/4885
US-20060052374-A1 Amino-tetrazole analogues and methods of use P2RX7, P2RX2, P2RX3 ALDH1A1 3045/4885NPSR1 198/4885TDP1 1904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.