Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 5/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914564 | 0.85 | LMNA (0.50) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL4905932 | 0.84 | PDE2A (0.49) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL28186848 | 0.82 | PDE2A (0.47) | PDE2AHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL4914691 | 0.82 | RORC (0.56) | HTR2BPDE2AHSP90AA1HSP90AB1MEN1 | |
| SCHEMBL5167842 | 0.82 | ALDH1A1 (0.59) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL12889906 | 0.81 | PDE2A (0.53) | HTR2BPDE2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL9798152 | 0.80 | PDE2A (0.46) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL10304787 | 0.79 | PDE2A (0.52) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL84521 | 0.78 | PDE2A (0.70) | PDE2A | |
| SCHEMBL8291096 | 0.78 | PDE2A (0.50) | HTR2BPDE2AHSP90AA1HSP90AB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4960539-A | Use of fluoromethylphenols as solvents for LC-polymers, and new fluoromethylphenols | BAYER AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | claimed |
| US-20220162209-A1 | SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2022-05-26 | — | — | US | disclosed |
| WO-2020132603-A2 | SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-06-25 | — | — | WO | disclosed |
| US-20180118680-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | GENENTECH, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-20160221945-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | GENENTECH, INC. (US) | 2016-08-04 | — | — | US | disclosed |
| EP-2307394-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Amorepacific Corporation (KR) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010002209-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2010-01-07 | — | — | WO | disclosed |
| US-20080312339-A1 | FLUORINE-SUBSTITUTED ALKYL PHENOL COMPOUNDS AND THEIR USES | BAKER MAX T | 2008-12-18 | — | — | US | disclosed |
| US-7312250-B2 | Fluorine-substituted alkyl phenol compounds and their uses | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2003077894-A1 | FLUORINE-SUBSTITUTED ALKYL PHENOL COMPOUNDS AND THEIR USES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2003-09-25 | — | — | WO | disclosed |
| US-20030176513-A1 | Fluorine-substituted alkyl phenol compounds and their uses | IOWA RESEARCH FOUNDATION, UNIVERSITY OF | 2003-09-18 | — | — | US | disclosed |
| US-4960539-A | Use of fluoromethylphenols as solvents for LC-polymers, and new fluoromethylphenols | BAYER AKTIENGESELLSCHAFT (DE) | 1990-10-02 | — | — | US | disclosed |
| EP-0286953-B1 | USE OF FLUOROMETHYL PHENOLS AS SOLVENTS FOR LC POLYMERS, AND FLUOROMETHYL PHENOLS | BAYER AG (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0286953-A1 | Use of fluoromethyl phenols as solvents for LC polymers, and fluoromethyl phenols | BAYER AG (DE) | 1988-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221945-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | LMNA 3964/4885TRPA1 1/4885CHRM1 2859/4885 |
| US-20030176513-A1 | Fluorine-substituted alkyl phenol compounds and their uses | AFF4, AFF1, AFF2 | LMNA 4011/4885TRPA1 221/4885CHRM1 217/4885 |
| US-20180118680-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | LMNA 3964/4885TRPA1 1/4885CHRM1 2859/4885 |
| US-20220162209-A1 | SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF | ADSL, SLC35B2, ADORA1 | LMNA 3181/4885TRPA1 1065/4885CHRM1 1257/4885 |
| US-20080312339-A1 | FLUORINE-SUBSTITUTED ALKYL PHENOL COMPOUNDS AND THEIR USES | AFF4, AFF1, AFF2 | LMNA 4011/4885TRPA1 221/4885CHRM1 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.