Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962150 | 0.84 | CASP3 (0.33) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL13340953 | 0.81 | OPRK1 (0.34) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL9269968 | 0.80 | PKM (0.42) | ALDH1A1EPHX2MAPTKMT2AMEN1 | |
| SCHEMBL13212473 | 0.73 | MAPT (0.48) | ALDH1A1MAPTKMT2AMAPK1MEN1 | |
| SCHEMBL5543415 | 0.73 | CYP2C9 (0.49) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL16601582 | 0.70 | ALDH1A1 (0.38) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL13367651 | 0.70 | RXRA (0.43) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL13434186 | 0.68 | TSHR (0.36) | CYP2C9ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL628451 | 0.67 | KDM1A (0.49) | CYP2C19ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL16601592 | 0.66 | KMT2A (0.38) | CYP2C9CYP2C19ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |