Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961732 | 0.84 | CASP3 (0.33) | ALDH1A1KMT2AMEN1PKMSMN1; SMN2 | |
| SCHEMBL13340959 | 0.81 | OPRK1 (0.34) | ALDH1A1KMT2AMEN1MAPTPKM | |
| SCHEMBL16601583 | 0.80 | PKM (0.42) | ALDH1A1KMT2AMEN1MAPTCA12 | |
| SCHEMBL16601584 | 0.76 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1MAPTCA12 | |
| SCHEMBL5543415 | 0.73 | CYP2C9 (0.49) | ALDH1A1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL13367651 | 0.73 | RXRA (0.43) | ALDH1A1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL16601603 | 0.70 | CYP2C9 (0.41) | ALDH1A1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL16601592 | 0.66 | KMT2A (0.38) | ALDH1A1KMT2AMEN1CYP2C9CYP2C19 | |
| SCHEMBL13261336 | 0.65 | CA1 (0.44) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL435242 | 0.64 | ATAD2 (0.69) | ALDH1A1KMT2AMEN1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |