Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612739 | 0.83 | TDP1 (0.54) | LMNAEGLN3TDP1KDM4ENPC1 | |
| SCHEMBL16612954 | 0.82 | LMNA (0.53) | LMNA | |
| SCHEMBL16612613 | 0.81 | MTNR1A (0.49) | HCRTR2P2RX7LMNASLC22A12 | |
| SCHEMBL16612920 | 0.75 | CDK4 (0.52) | LMNA | |
| SCHEMBL16612745 | 0.74 | HDAC6 (0.42) | HCRTR2LMNA | |
| SCHEMBL12480072 | 0.74 | HTR2A (0.41) | HCRTR2LMNA | |
| SCHEMBL16612876 | 0.74 | HTR2C (0.41) | HCRTR2P2RX7LMNA | |
| SCHEMBL16613000 | 0.74 | HTR2A (0.42) | HCRTR2LMNAJAK2JAK1TYK2 | |
| SCHEMBL16612960 | 0.73 | HCRTR2 (0.41) | METHCRTR2KDM4E | |
| SCHEMBL16612831 | 0.72 | HCRTR2 (0.42) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |