Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.31 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613148 | 0.84 | HCRTR2 (0.42) | HCRTR2 | |
| SCHEMBL16612997 | 0.78 | HCRTR2 (0.42) | HCRTR2TRPM5 | |
| SCHEMBL16613015 | 0.78 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL16612613 | 0.77 | MTNR1A (0.49) | HCRTR2 | |
| SCHEMBL16612773 | 0.77 | MTNR1A (0.53) | HCRTR2 | |
| SCHEMBL16612831 | 0.77 | HCRTR2 (0.42) | HCRTR2TRPM5 | |
| SCHEMBL16612656 | 0.73 | HCRTR2 (0.42) | HCRTR2TRPM5 | |
| SCHEMBL16612704 | 0.73 | MET (0.41) | HCRTR2KDM4EMET | |
| SCHEMBL16613026 | 0.72 | HDAC6 (0.40) | HCRTR2KDR | |
| SCHEMBL16612868 | 0.72 | MTNR1A (0.49) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |