Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612920 | 0.93 | CDK4 (0.52) | LMNACDK4CCND1MAPK1KMT2A | |
| SCHEMBL16612876 | 0.83 | HTR2C (0.41) | LMNAMTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL12480072 | 0.83 | HTR2A (0.41) | LMNACDK4CCND1HTR2AHTR2C | |
| SCHEMBL16613000 | 0.83 | HTR2A (0.42) | LMNACDK4CCND1MTNR1AMTNR1B | |
| SCHEMBL16612854 | 0.83 | MTNR1A (0.52) | LMNAKMT2AMTNR1AMTNR1BHSD17B10 | |
| SCHEMBL16612745 | 0.82 | HDAC6 (0.42) | LMNACYP1A2CYP3A4HTR2AHTR2C | |
| SCHEMBL16612613 | 0.82 | MTNR1A (0.49) | LMNAMTNR1ADAO | |
| SCHEMBL16612704 | 0.82 | MET (0.41) | LMNA | |
| SCHEMBL16612868 | 0.82 | MTNR1A (0.49) | LMNAMTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL16612790 | 0.81 | HCRTR2 (0.39) | LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |