SCHEMBL16612831

SCHEMBL16612831

COc1cc2ccn(CCn3c[c]c(C(N)=O)n3)c2cc1OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 9/20 0.42
HCRTR1 O43613 1/20 0.40
HDAC3 O15379 2/20 0.39
HDAC1 Q13547 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
NCOR2 Q9Y618 1/20 0.39
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39
TRPM5 Q9NZQ8 1/20 0.37
TNF P01375 2/20 0.36
MTNR1A P48039 2/20 0.35
MTNR1B P49286 2/20 0.35
HDAC10 Q969S8 1/20 0.35
TUBB4A P04350 2/20 0.34
TUBB P07437 2/20 0.34
TUBA3C P0DPH7 2/20 0.34
TUBA1B P68363 2/20 0.34
TUBA4A P68366 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16612656 0.92 HCRTR2 (0.42) HCRTR2HCRTR1HDAC3HDAC1HDAC2
SCHEMBL16612868 0.87 MTNR1A (0.49) HCRTR2HCRTR1HDAC3HDAC1HDAC2
SCHEMBL16612854 0.86 MTNR1A (0.52) HCRTR2HCRTR1HDAC3HDAC1HDAC2
SCHEMBL16612628 0.84 HCRTR2 (0.43) HCRTR2HCRTR1MTNR1AMTNR1B
SCHEMBL16612982 0.84 HCRTR2 (0.44) HCRTR2HCRTR1MTNR1AMTNR1B
SCHEMBL16612745 0.83 HDAC6 (0.42) HCRTR2HDAC1HDAC8HDAC6
SCHEMBL16613000 0.82 HTR2A (0.42) HCRTR2HCRTR1HDAC3HDAC1HDAC2
SCHEMBL16612997 0.82 HCRTR2 (0.42) HCRTR2HCRTR1TSHRHTTTRPM5
SCHEMBL16613026 0.80 HDAC6 (0.40) HCRTR2HDAC6TNFMTNR1AMTNR1B
SCHEMBL16612936 0.80 MTNR1A (0.50) HCRTR2MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2675801-B1 NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2015-04-08 EP claimed