Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612954 | 0.82 | LMNA (0.53) | MTNR1ADAOLMNA | |
| SCHEMBL16612871 | 0.81 | HCRTR2 (0.36) | MTNR1AHCRTR2 | |
| SCHEMBL16612704 | 0.81 | MET (0.41) | HCRTR2P2RX7SLC22A12LMNA | |
| SCHEMBL16612773 | 0.79 | MTNR1A (0.53) | MTNR1APARP1HCRTR1HCRTR2 | |
| SCHEMBL16612705 | 0.78 | HCRTR2 (0.38) | HCRTR2LMNA | |
| SCHEMBL16612790 | 0.78 | HCRTR2 (0.39) | HCRTR2P2RX7LMNA | |
| SCHEMBL16612960 | 0.77 | HCRTR2 (0.41) | HCRTR2 | |
| SCHEMBL16612920 | 0.75 | CDK4 (0.52) | MTNR1ALMNA | |
| SCHEMBL16612745 | 0.74 | HDAC6 (0.42) | HCRTR2LMNA | |
| SCHEMBL12480072 | 0.74 | HTR2A (0.41) | HCRTR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |