Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612854 | 0.84 | MTNR1A (0.52) | HTR2CHTR2AHTR7HCRTR2LMNA | |
| SCHEMBL16612954 | 0.83 | LMNA (0.53) | HTR2CHTR2ALMNAMTNR1AMTNR1B | |
| SCHEMBL16612745 | 0.83 | HDAC6 (0.42) | HTR2CHTR2AHCRTR2KMOLMNA | |
| SCHEMBL16612831 | 0.80 | HCRTR2 (0.42) | HCRTR2MTNR1AMTNR1B | |
| SCHEMBL12480072 | 0.80 | HTR2A (0.41) | HTR2CHTR2AHCRTR2KMOLMNA | |
| SCHEMBL16613000 | 0.80 | HTR2A (0.42) | HTR2CHTR2AHTR7HCRTR2LMNA | |
| SCHEMBL16612868 | 0.78 | MTNR1A (0.49) | HTR2CHTR2AHCRTR2LMNAMTNR1A | |
| SCHEMBL16612628 | 0.78 | HCRTR2 (0.43) | HCRTR2MTNR1AMTNR1B | |
| SCHEMBL16612936 | 0.78 | MTNR1A (0.50) | HTR2CHTR2AHTR7HCRTR2MTNR1A | |
| SCHEMBL16612705 | 0.77 | HCRTR2 (0.38) | HCRTR2HTR1ASLC6A4LMNAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |