Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612705 | 0.86 | HCRTR2 (0.38) | HCRTR2LMNACXCR3HTR1ASLC6A4 | |
| SCHEMBL16612954 | 0.81 | LMNA (0.53) | LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16613000 | 0.80 | HTR2A (0.42) | HCRTR2LMNAMAPT | |
| SCHEMBL16612613 | 0.78 | MTNR1A (0.49) | HCRTR2P2RX7LMNA | |
| SCHEMBL16612920 | 0.74 | CDK4 (0.52) | LMNASMN1; SMN2 | |
| SCHEMBL16612745 | 0.74 | HDAC6 (0.42) | HCRTR2LMNACXCR3 | |
| SCHEMBL16612871 | 0.74 | HCRTR2 (0.36) | HCRTR2CXCR3 | |
| SCHEMBL16612831 | 0.73 | HCRTR2 (0.42) | HCRTR2 | |
| SCHEMBL16612773 | 0.73 | MTNR1A (0.53) | HCRTR2CXCR3 | |
| SCHEMBL16612868 | 0.73 | MTNR1A (0.49) | HCRTR2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |