Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 16/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.38 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612628 | 0.92 | HCRTR2 (0.43) | HCRTR2HCRTR1NNMTMTNR1AMTNR1B | |
| SCHEMBL16612868 | 0.84 | MTNR1A (0.49) | HCRTR2HCRTR1MTNR1AMTNR1B | |
| SCHEMBL16612831 | 0.84 | HCRTR2 (0.42) | HCRTR2HCRTR1MTNR1AMTNR1B | |
| SCHEMBL16613000 | 0.82 | HTR2A (0.42) | HCRTR2HCRTR1MAPTMTNR1AMTNR1B | |
| SCHEMBL16612854 | 0.81 | MTNR1A (0.52) | HCRTR2HCRTR1MTNR1AMTNR1B | |
| SCHEMBL16612656 | 0.81 | HCRTR2 (0.42) | HCRTR2HCRTR1MTNR1AMTNR1B | |
| SCHEMBL16612773 | 0.80 | MTNR1A (0.53) | HCRTR2HCRTR1NNMTMTNR1AMTNR1B | |
| SCHEMBL16612745 | 0.78 | HDAC6 (0.42) | HCRTR2 | |
| SCHEMBL12480072 | 0.78 | HTR2A (0.41) | HCRTR2MAPT | |
| SCHEMBL16612954 | 0.77 | LMNA (0.53) | MAPTMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |