Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849204 | 0.86 | GAA (0.36) | DDB1CRBNHDAC4GAAJAK2 | |
| SCHEMBL17849219 | 0.73 | RAF1 (0.42) | GAAMAPT | |
| SCHEMBL16623479 | 0.73 | CRBN (0.40) | CRBNBRD4CREBBP | |
| SCHEMBL16623480 | 0.73 | MAPK14 (0.34) | — | |
| SCHEMBL16623554 | 0.73 | MAPK14 (0.33) | JAK2JAK1JAK3 | |
| SCHEMBL16623594 | 0.69 | CMA1 (0.35) | — | |
| SCHEMBL17849236 | 0.62 | RORC (0.36) | GAA | |
| SCHEMBL16726675 | 0.61 | — | — | |
| SCHEMBL17849237 | 0.61 | RORC (0.33) | — | |
| SCHEMBL24237192 | 0.61 | ACHE (0.50) | HDAC4MAPTJAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |