Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072323 | 0.86 | CYP2C9 (0.38) | ALDH1A1ALOX15CYP2C9PLCG2NFKB1 | |
| SCHEMBL16626762 | 0.84 | ALDH1A1 (0.40) | ALDH1A1ALOX15GAAL3MBTL1PKM | |
| SCHEMBL28501604 | 0.83 | CYP2C9 (0.35) | ALDH1A1ALOX15CYP2C9PLCG2NFKB1 | |
| SCHEMBL28904108 | 0.82 | CYP2C9 (0.39) | ALDH1A1ALOX15CYP2C9PLCG2NFKB1 | |
| SCHEMBL28233891 | 0.81 | CYP2C9 (0.34) | ALDH1A1ALOX15CYP2C9PLCG2NFKB1 | |
| SCHEMBL21693930 | 0.79 | CYP2C9 (0.33) | ALDH1A1ALOX15CYP2C9PLCG2NFKB1 | |
| SCHEMBL5073003 | 0.77 | ALOX15 (0.44) | ALOX15CYP2C9PLCG2NFKB1NFKB2 | |
| SCHEMBL16626765 | 0.76 | ALDH1A1 (0.49) | ALDH1A1ALOX15GAAL3MBTL1PKM | |
| SCHEMBL19424008 | 0.74 | ALDH1A1 (0.45) | ALDH1A1ALOX15GAAKDM4E | |
| SCHEMBL15710982 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10780026-B2 | Methods of forming dental composites and compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2020-09-22 | — | — | US | disclosed |
| US-20190224081-A1 | METHODS OF FORMING DENTAL COMPOSITES AND COMPOSITIONS FOR REDUCED SHRINKAGE STRESS | DENTSPLY SIRONA INC (US) | 2019-07-25 | — | — | US | disclosed |
| US-9931280-B2 | Dental composite compositions for reduced shrinkage stress | DENTSPLY SIRONA INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | DENTSPLY SIRONA INC. | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099821-A1 | DENTAL COMPOSITE COMPOSITIONS FOR REDUCED STRESS SHRINKAGE | VCL, HSPA4L, GPX4 | ALDH1A1 2471/4885ALOX15 598/4885CYP2C9 4005/4885 |
| US-10780026-B2 | Methods of forming dental composites and compositions for reduced shrinkage stress | SMCHD1, FHIT, ACR | ALDH1A1 1551/4885ALOX15 387/4885CYP2C9 2856/4885 |
| US-20190224081-A1 | METHODS OF FORMING DENTAL COMPOSITES AND COMPOSITIONS FOR REDUCED SHRINKAGE STRESS | SMCHD1, FHIT, ACR | ALDH1A1 1551/4885ALOX15 387/4885CYP2C9 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.