Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16628323 | 0.83 | KLKB1 (0.47) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16628263 | 0.81 | POLB (0.56) | POLBMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL22001753 | 0.78 | POLB (0.53) | POLBMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21043473 | 0.77 | ALDH1A1 (0.56) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22001752 | 0.76 | CHRM1 (0.59) | — | |
| SCHEMBL19997556 | 0.75 | RPS6KB1 (0.42) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16628259 | 0.72 | ADRA1D (0.50) | MAPTHTTCNR2ADRA1D | |
| SCHEMBL16628330 | 0.72 | CHRM1 (0.43) | POLBMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16593276 | 0.71 | POLB (0.56) | POLBMAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL21042584 | 0.71 | POLB (0.42) | POLBMAPTALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |