Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21042784 | 0.83 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL16586481 | 0.79 | ENPP2 (0.60) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL21042783 | 0.79 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL16628332 | 0.77 | POLB (0.46) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL22001748 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL8690446 | 0.72 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL16596364 | 0.72 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL22001279 | 0.69 | CHRM1 (0.46) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL22001176 | 0.69 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT | |
| SCHEMBL22001366 | 0.69 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |