Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MYC | P01106 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAT2A | P31153 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634615 | 0.84 | RORC (0.46) | TP53HSP90AA1LMNAKMT2AL3MBTL1 | |
| SCHEMBL16634744 | 0.77 | L3MBTL1 (0.55) | HSP90AA1LMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL10743256 | 0.76 | KDM4E (0.73) | TP53HSP90AA1LMNAKMT2AL3MBTL1 | |
| SCHEMBL23119669 | 0.75 | LMNA (0.67) | TP53HSP90AA1LMNAKMT2AL3MBTL1 | |
| SCHEMBL29367625 | 0.75 | LMNA (0.65) | HSP90AA1LMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL699273 | 0.75 | LMNA (0.65) | HSP90AA1LMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL5786423 | 0.72 | MYC (0.70) | TP53MYCNR4A1KMT2AL3MBTL1 | |
| SCHEMBL9559146 | 0.72 | HSP90AA1 (0.62) | TP53HSP90AA1LMNAKMT2AL3MBTL1 | |
| SCHEMBL30615679 | 0.71 | MAT2A (0.49) | HSP90AA1LMNAKMT2AL3MBTL1MEN1 | |
| SCHEMBL18919887 | 0.71 | L3MBTL1 (0.57) | TP53HSP90AA1LMNAKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |